Wogonin


Catalog No. size PriceQuantity
M6930-2 2mg solid $122
M6930-10 10mg solid $482

Description

Cas:632-85-9

Product Information:

Wogonin, a flavonoid isolated from Scutellaria baicalensis Georgi, exhibits potent anti-tumor effects in vivo and in vitro.

 

Chemical Formula: C16H12O5

 

Exact Mass: 284.0685

 

Molecular Weight: 284.267

 

Elemental Analysis: C, 67.60; H, 4.26; O, 28.14

 

Chemical Name: 

4H-1-Benzopyran-4-one, 5,7-dihydroxy-8-methoxy-2-phenyl-

 

InChi Key: 

XLTFNNCXVBYBSX-UHFFFAOYSA-N

 

InChi Code: 

InChI=1S/C16H12O5/c1-20-15-12(19)7-10(17)14-11(18)8-13(21-16(14)15)9-5-3-2-4-6-9/h2-8,17,19H,1H3

 

Smiles Code:

O=C1C=C(C2=CC=CC=C2)OC3=C(OC)C(O)=CC(O)=C13

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

 

In Vitro:

Wogonin (0-200 μM) exhibits a dose- and time- dependent reduces in cell viability of caco-2, SW1116 and HCT116 cells. Wogonin (10-40 μM) induces G1 phase arrest in HCT-116 cells. Wogonin also supresses Wnt signaling pathway in HCT116 cells. Wogonin interfers in the activity of transcription factor TCF/Lef family. Moreover, Wogonin inhibits β-catenin-mediated transcription through suppressing the activity of CDK8. Wogonin shows cytotoxic and antiproliferative effects on HeLa cells. Wogonin (90 µM) induces cell cycle arrest at G0-G1 phase, and suppresses the levels of cyclin D1 and Cdk4 markedly in HeLa cells[2]. Wogonin (1.25, 2.5, 5, 10, 20 μg/ml) suppresses EtOH-induced inflammatory response in RAW264.7 cells.

 

In Vivo:

Wogonin (30, 60 mg/kg) reduces tumor growth of HCT116 cells in a xenograft model. Wogonin (25, 50, 100 mg/kg) protects against liver injury and pathological characteristics of ALD in mice. Wogonin activates PPAR-γ expression in mice with ALD and EtOH induced RAW264.7 cells.

 

 

References:

 

  1. Zhao Y, Zhang L, Wu Y, Dai Q, Zhou Y, Li Z, Yang L, Guo Q, Lu N. Selective anti-tumor activity of wogonin targeting the Warburg effect through stablizing p53. Pharmacol Res. 2018 Jul 18;135:49-59. doi: 10.1016/j.phrs.2018.07.011. [Epub ahead of print] PubMed PMID: 30031170.

 

  1. Yang W, He S, Xiao N, Qiao Y, Sui H, Liang L, Chen J, Li W, Zhang L. Simultaneous Determination of 15 Flavonoids in Scutellaria barbata-Hedyotis diffusa Herb Pair by HPLC Q-TOF MS. J AOAC Int. 2018 Jul 20. doi: 10.5740/jaoacint.17-0469. [Epub ahead of print] PubMed PMID: 30029697.

 

  1. Go JH, Wei JD, Park JI, Ahn KS, Kim JH. Wogonin suppresses the LPS enhanced invasiveness of MDA MB 231 breast cancer cells by inhibiting the 5 LO/BLT2 cascade. Int J Mol Med. 2018 Jul 12. doi: 10.3892/ijmm.2018.3776. [Epub ahead of print] PubMed PMID: 30015917.

 

  1. Jintao X, Quanwei Y, Chunyan L, Yun J, Shuangxi W, Mingxiang Z, Peng L. Rapid and Simultaneous Determination of Three Active Components in Raw and Processed Root Samples of Scutellaria baicalensis by Near-infrared Spectroscopy. Planta Med. 2018 Jul 13. doi: 10.1055/a-0655-2211. [Epub ahead of print] PubMed PMID: 30005428.

 

  1. Kim KA, Jung JH, Choi YS, Kang G, Kim ST. Anti-inflammatory effect of wogonin on allergic responses in ovalbumin-induced allergic rhinitis in the mouse. Allergy Rhinol (Providence). 2018 Apr 9;9:2152656718764145. doi: 10.1177/2152656718764145. eCollection 2018 Jan-Dec. PubMed PMID: 29977652; PubMed Central PMCID: PMC6028163.

 

Products are for research use only. Not for human use.

 

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