Wogonin

Wogonin, a flavonoid isolated from Scutellaria baicalensis Georgi, exhibits potent anti-tumor effects in vivo and in vitro.

Product information

CAS Number: 632-85-9

Molecular Weight: 284.26

Formula: C16H12O5

Chemical Name: 4H-1-Benzopyran-4-one, 5,7-dihydroxy-8-methoxy-2-phenyl-

Smiles: COC1=C2OC(=CC(=O)C2=C(O)C=C1O)C1C=CC=CC=1

InChiKey: XLTFNNCXVBYBSX-UHFFFAOYSA-N

InChi: InChI=1S/C16H12O5/c1-20-15-12(19)7-10(17)14-11(18)8-13(21-16(14)15)9-5-3-2-4-6-9/h2-8,17,19H,1H3

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

Wogonin (0-200 μM) exhibits a dose- and time- dependent reduces in cell viability of caco-2, SW1116 and HCT116 cells. Wogonin (10-40 μM) induces G1 phase arrest in HCT-116 cells. Wogonin also supresses Wnt signaling pathway in HCT116 cells. Wogonin interfers in the activity of transcription factor TCF/Lef family. Moreover, Wogonin inhibits β-catenin-mediated transcription through suppressing the activity of CDK8. Wogonin shows cytotoxic and antiproliferative effects on HeLa cells. Wogonin (90 µM) induces cell cycle arrest at G0-G1 phase, and suppresses the levels of cyclin D1 and Cdk4 markedly in HeLa cells. Wogonin (1.25, 2.5, 5, 10, 20 μg/ml) suppresses EtOH-induced inflammatory response in RAW264.7 cells.

In Vivo:

Wogonin (30, 60 mg/kg) reduces tumor growth of HCT116 cells in a xenograft model. Wogonin (25, 50, 100 mg/kg) protects against liver injury and pathological characteristics of ALD in mice. Wogonin activates PPAR-γ expression in mice with ALD and EtOH induced RAW264.7 cells.

References:

1. Zhao Y, Zhang L, Wu Y, Dai Q, Zhou Y, Li Z, Yang L, Guo Q, Lu N. Selective anti-tumor activity of wogonin targeting the Warburg effect through stablizing p53. Pharmacol Res. 2018 Jul 18;135:49-59. doi: 10.1016/j.phrs.2018.07.011. [Epub ahead of print] PubMed PMID: 30031170.
2. Yang W, He S, Xiao N, Qiao Y, Sui H, Liang L, Chen J, Li W, Zhang L. Simultaneous Determination of 15 Flavonoids in Scutellaria barbata-Hedyotis diffusa Herb Pair by HPLC Q-TOF MS. J AOAC Int. 2018 Jul 20. doi: 10.5740/jaoacint.17-0469. [Epub ahead of print] PubMed PMID: 30029697.
3. Go JH, Wei JD, Park JI, Ahn KS, Kim JH. Wogonin suppresses the LPS enhanced invasiveness of MDA MB 231 breast cancer cells by inhibiting the 5 LO/BLT2 cascade. Int J Mol Med. 2018 Jul 12. doi: 10.3892/ijmm.2018.3776. [Epub ahead of print] PubMed PMID: 30015917.

Products are for research use only. Not for human use.