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M6930-2 2mg solid $122
M6930-10 10mg solid $482


Wogonin, a flavonoid isolated from Scutellaria baicalensis Georgi, exhibits potent anti-tumor effects in vivo and in vitro.

Product information

CAS Number: 632-85-9

Molecular Weight: 284.26

Formula: C16H12O5

Chemical Name: 4H-1-Benzopyran-4-one, 5,7-dihydroxy-8-methoxy-2-phenyl-

Smiles: COC1=C2OC(=CC(=O)C2=C(O)C=C1O)C1C=CC=CC=1


InChi: InChI=1S/C16H12O5/c1-20-15-12(19)7-10(17)14-11(18)8-13(21-16(14)15)9-5-3-2-4-6-9/h2-8,17,19H,1H3

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

Wogonin (0-200 μM) exhibits a dose- and time- dependent reduces in cell viability of caco-2, SW1116 and HCT116 cells. Wogonin (10-40 μM) induces G1 phase arrest in HCT-116 cells. Wogonin also supresses Wnt signaling pathway in HCT116 cells. Wogonin interfers in the activity of transcription factor TCF/Lef family. Moreover, Wogonin inhibits β-catenin-mediated transcription through suppressing the activity of CDK8. Wogonin shows cytotoxic and antiproliferative effects on HeLa cells. Wogonin (90 µM) induces cell cycle arrest at G0-G1 phase, and suppresses the levels of cyclin D1 and Cdk4 markedly in HeLa cells. Wogonin (1.25, 2.5, 5, 10, 20 μg/ml) suppresses EtOH-induced inflammatory response in RAW264.7 cells.

In Vivo:

Wogonin (30, 60 mg/kg) reduces tumor growth of HCT116 cells in a xenograft model. Wogonin (25, 50, 100 mg/kg) protects against liver injury and pathological characteristics of ALD in mice. Wogonin activates PPAR-γ expression in mice with ALD and EtOH induced RAW264.7 cells.


  1. Zhao Y, Zhang L, Wu Y, Dai Q, Zhou Y, Li Z, Yang L, Guo Q, Lu N. Selective anti-tumor activity of wogonin targeting the Warburg effect through stablizing p53. Pharmacol Res. 2018 Jul 18;135:49-59. doi: 10.1016/j.phrs.2018.07.011. [Epub ahead of print] PubMed PMID: 30031170.
  2. Yang W, He S, Xiao N, Qiao Y, Sui H, Liang L, Chen J, Li W, Zhang L. Simultaneous Determination of 15 Flavonoids in Scutellaria barbata-Hedyotis diffusa Herb Pair by HPLC Q-TOF MS. J AOAC Int. 2018 Jul 20. doi: 10.5740/jaoacint.17-0469. [Epub ahead of print] PubMed PMID: 30029697.
  3. Go JH, Wei JD, Park JI, Ahn KS, Kim JH. Wogonin suppresses the LPS enhanced invasiveness of MDA MB 231 breast cancer cells by inhibiting the 5 LO/BLT2 cascade. Int J Mol Med. 2018 Jul 12. doi: 10.3892/ijmm.2018.3776. [Epub ahead of print] PubMed PMID: 30015917.

Products are for research use only. Not for human use.

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