IQ 1


Catalog No. size PriceQuantity
M6943-2 2mg solid $126
M6943-10 10mg solid $522

Description

Cas:331001-62-8

Product Information:

IQ 1 has many functions such as decreasing Wnt-stimulated phosphorylation, maintaining the pluripotency of murine ESCs, preventing PP2A/Nkd interaction and so on. IQ 1 maintains the pluripotency of murine ESCs in long-term culture in a Wnt-dependent manner. IQ 1 decreased Wnt-stimulated phosphorylation of p300 at Ser-89.IQ-1 binds to serine/threonine phosphatase PP2A and prevents PP2A/Nkd interaction.The binding of IQ 1 to PR72/130 leads to decreased phosphorylation of the coactivator protein p300 at Ser-89. IQ 1 thereby diminishes the β-catenin/p300 interaction and prevents β-catenin coactivator switching from CBP to p300.

 

Molecular Weight: 362.42

 

Formula: C₂₁H₂₂N₄O₂

 

Smiles:

CC(C1=CC=C(/N=N/C(C(N)=O)=C2NC(C)(C)CC3=CC=CC=C3/2)C=C1)=O

Shipping:

Room temperature in continental US; may vary elsewhere.

 

Storage:

Powder    -20°C  3 years

4°C  2 years

In solvent -80°C  6 months

-20°C  1 month

 

 

References:

 

  1. Miyabayashi T et al. Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency. Proc Natl Acad Sci U S A, 2007 Mar 27, 104(13):5668-73.

 

Products are for research use only. Not for human use.

 

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