Catalog No. size PriceQuantity
M6944-2 2mg solid $100
M6944-10 10mg solid $406



Product Information:

Triptonide is a Wnt/β-catenin inhibitor. Triptonide can effectively inhibit canonical Wnt/β-catenin signaling by targeting the downstream C-terminal transcription domain of β-catenin or a nuclear component associated with β-catenin. It also effectively induced apoptosis of Wnt-dependent cancer cells, supporting the therapeutic potential of triptonide.


Chemical Formula: C20H22O6


Exact Mass: 358.1416


Molecular Weight: 358.39


Elemental Analysis: C, 67.03; H, 6.19; O, 26.78


Chemical Name: 



InChi Key:



InChi Code: 



Smiles Code: 




Technical Data:


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001





  1. Zhang H, Li H, Xue J, Chen R, Li Y, Tang Y, Li C. New facile enantio- and diastereo-selective syntheses of (-)-triptonide and (-)-triptolide. Org Biomol Chem. 2014 Feb 7;12(5):732-6. doi: 10.1039/c3ob42183j. Epub 2013 Dec 18. PubMed PMID: 24346247.


  1. Xu H, Tang H, Feng H, Li Y. Divergent total synthesis of triptolide, triptonide, tripdiolide, 16-hydroxytriptolide, and their analogues. J Org Chem. 2014 Nov 7;79(21):10110-22. doi: 10.1021/jo501744j. Epub 2014 Oct 24. PubMed PMID: 25296383.


  1. Chinison J, Aguilar JS, Avalos A, Huang Y, Wang Z, Cameron DJ, Hao J. Triptonide Effectively Inhibits Wnt/β-Catenin Signaling via C-terminal Transactivation Domain of β-catenin. Sci Rep. 2016 Sep 6;6:32779. doi: 10.1038/srep32779. PubMed PMID: 27596363; PubMed Central PMCID: PMC5011721.


  1. He L, Liang Z, Zhao F, Peng L, Chen Z. Modulation of IL-37 expression by triptolide and triptonide in THP-1 cells. Cell Mol Immunol. 2015 Jul;12(4):515-8. doi: 10.1038/cmi.2014.92. Epub 2014 Oct 13. PubMed PMID: 25308753; PubMed Central PMCID: PMC4496545.


  1. Gang YY, Zhang ZX, Zhang SQ, Liu XD, An DK. [Pharmacokinetics and disposition of triptonide in rats]. Yao Xue Xue Bao. 1996;31(12):901-5. Chinese. PubMed PMID: 9863222.


Products are for research use only. Not for human use.

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