Methyl vanillate

Catalog No. size PriceQuantity
M6947-2 2mg solid $78
M6947-10 10mg solid $324


Methyl vanillate is isolated from Hovenia dulcis.

Product information

CAS Number: 3943-74-6

Molecular Weight: 182.17

Formula: C9H10O4


NSC 74385

Methyl vanillate

Chemical Name: Benzoic acid, 4-hydroxy-3-methoxy-, methyl ester

Smiles: COC1=CC(=CC=C1O)C(=O)OC


InChi: InChI=1S/C9H10O4/c1-12-8-5-6(9(11)13-2)3-4-7(8)10/h3-5,10H,1-2H3

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

Methyl vanillate (0-100 μM) increases the expression and nuclear translocation of β-catenin in calvarial osteoblasts. Methyl vanillate dose-dependently elevates ALP activity in calvarial osteoblasts.


  1. Al Bujuq N, Arar S, Khalil R. Synthesis and cytotoxic activity of 4-O-β-D-galactopyranosyl derivatives of phenolic acids esters. Nat Prod Res. 2017 Sep 18:1-7. doi: 10.1080/14786419.2017.1375927. [Epub ahead of print] PubMed PMID: 28920447.
  2. Lim SJ, Kim M, Randy A, Nam EJ, Nho CW. Effects of Hovenia dulcis Thunb. extract and methyl vanillate on atopic dermatitis-like skin lesions and TNF-α/IFN-γ-induced chemokines production in HaCaT cells. J Pharm Pharmacol. 2016 Nov;68(11):1465-1479. doi: 10.1111/jphp.12640. Epub 2016 Oct 2. PubMed PMID: 27696405.
  3. Ishimata N, Ito H, Tai A. Structure-activity relationships of vanillic acid ester analogs in inhibitory effect of antigen-mediated degranulation in rat basophilic leukemia RBL-2H3 cells. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3533-6. doi: 10.1016/j.bmcl.2016.06.028. Epub 2016 Jun 11. PubMed PMID: 27324979.

Products are for research use only. Not for human use.

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