Methyl vanillate

Catalog No. size PriceQuantity
M6947-2 2mg solid $78
M6947-10 10mg solid $324



Product Information:

Methyl vanillate is isolated from Hovenia dulcis.


Chemical Formula: C9H10O4


Exact Mass: 182.0579


Molecular Weight: 182.18


Elemental Analysis: C, 59.34; H, 5.53; O, 35.13




Methyl vanillate

NSC 74385


Chemical Name: 

Benzoic acid, 4-hydroxy-3-methoxy-, methyl ester


InChi Key:



InChi Code:



Smiles Code:




Technical Data:


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00


In Vitro:

Methyl vanillate (0-100 μM) increases the expression and nuclear translocation of β-catenin in calvarial osteoblasts. Methyl vanillate dose-dependently elevates ALP activity in calvarial osteoblasts.





  1. Al Bujuq N, Arar S, Khalil R. Synthesis and cytotoxic activity of 4-O-β-D-galactopyranosyl derivatives of phenolic acids esters. Nat Prod Res. 2017 Sep 18:1-7. doi: 10.1080/14786419.2017.1375927. [Epub ahead of print] PubMed PMID: 28920447.


  1. Herrero P, Sáenz-Navajas MP, Avizcuri JM, Culleré L, Balda P, Antón EC, Ferreira V, Escudero A. Study of Chardonnay and Sauvignon blanc wines from D.O.Ca Rioja (Spain) aged in different French oak wood barrels: Chemical and aroma quality aspects. Food Res Int. 2016 Nov;89(Pt 1):227-236. doi: 10.1016/j.foodres.2016.08.002. Epub 2016 Aug 8. PubMed PMID: 28460909.


  1. Lim SJ, Kim M, Randy A, Nam EJ, Nho CW. Effects of Hovenia dulcis Thunb. extract and methyl vanillate on atopic dermatitis-like skin lesions and TNF-α/IFN-γ-induced chemokines production in HaCaT cells. J Pharm Pharmacol. 2016 Nov;68(11):1465-1479. doi: 10.1111/jphp.12640. Epub 2016 Oct 2. PubMed PMID: 27696405.


  1. Bellincontro A, Matarese F, D'Onofrio C, Accordini D, Tosi E, Mencarelli F. Management of postharvest grape withering to optimise the aroma of the final wine: A case study on Amarone. Food Chem. 2016 Dec 15;213:378-387. doi: 10.1016/j.foodchem.2016.06.098. Epub 2016 Jun 29. PubMed PMID: 27451194.


  1. Ishimata N, Ito H, Tai A. Structure-activity relationships of vanillic acid ester analogs in inhibitory effect of antigen-mediated degranulation in rat basophilic leukemia RBL-2H3 cells. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3533-6. doi: 10.1016/j.bmcl.2016.06.028. Epub 2016 Jun 11. PubMed PMID: 27324979.


Products are for research use only. Not for human use.


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