FIDAS-5


Catalog No. size PriceQuantity
M6949-2 2mg solid $126
M6949-10 10mg solid $516

Description

Cas:1391934-98-7

Product Information:

FIDAS-5 is a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM. FIDAS-5 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-5 has anticancer activities.

 

IC50 & Target: IC50: 2.1 μM (Methionine S-adenosyltransferase 2A (MAT2A))

 

Molecular Weight: 261.72

 

Formula: C₁₅H₁₃ClFN

 

Smiles:

CNC1=CC=C(/C=C/C2=C(F)C=CC=C2Cl)C=C1

 

Shipping:

Room temperature in continental US; may vary elsewhere.

 

Storage:

Powder    -20°C  3 years

4°C  2 years

 

In Vitro:

FIDAS-5 (3 μM; 7 days; LS174T cells) treatment significantly inhibits the proliferation of LS174T cells.

FIDAS-5 (3 μM) treatment inhibits the expression of c-Myc and cyclinD1 in LS174T CRC cells. And FIDAS-5 induces the expression of cell cycle inhibitor, p21WAF1/CIP1.

FIDAS-5 (3 μM; 36 h) treatment reduces the levels of both S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in LS174T cells.

 

In Vivo:

FIDAS-5 (20 mg/kg; oral gavage; daily; for two weeks; athymic nude mice) treatment significantly inhibits the growth of xenograft tumors, with minimal difference in body weight.

Mice are treated with FIDAS-5 (20 mg/kg) for 1 week. The liver SAM levels are significantly reduced.

 

 

References:

  1. Zhang W, et al. Fluorinated N,N-dialkylaminostilbenes repress colon cancer bytargeting methionine S-adenosyltransferase 2A. ACS Chem Biol. 2013 Apr 19;8(4):796-803.

 

Products are for research use only. Not for human use.

 

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