Neurodazine

Neurodazine is a neurogenic inducer for converting pluripotent P19 cells into electrophysiologically active neurons.

Product information

CAS Number: 937807-66-4

Molecular Weight: 456.92

Formula: C27H21ClN2O3

Chemical Name: 2-[5-(3-Chloro-phenyl)-furan-2-yl]-4,5-bis-(4-methoxy-phenyl)-1H-imidazole

Smiles: COC1C=CC(=CC=1)C1N=C(NC=1C1C=CC(=CC=1)OC)C1=CC=C(O1)C1=CC(Cl)=CC=C1

InChiKey: FEEOFPAEDSMOTO-UHFFFAOYSA-N

InChi: InChI=1S/C27H21ClN2O3/c1-31-21-10-6-17(7-11-21)25-26(18-8-12-22(32-2)13-9-18)30-27(29-25)24-15-14-23(33-24)19-4-3-5-20(28)16-19/h3-16H,1-2H3,(H,29,30)

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

References:

1. Halder D, Kim GH, Shin I. Synthetic small molecules that induce neuronal differentiation in neuroblastoma and fibroblast cells. Mol Biosyst. 2015 Oct;11(10):2727-37. doi: 10.1039/c5mb00161g. PubMed PMID: 25872738.
2. Pérez-Caaveiro C, Pérez Sestelo J, Martínez MM, Sarandeses LA. Triorganoindium reagents in selective palladium-catalyzed cross-coupling with iodoimidazoles: synthesis of neurodazine. J Org Chem. 2014 Oct 17;79(20):9586-93. doi: 10.1021/jo501664p. Epub 2014 Oct 1. PubMed PMID: 25203769.
3. Kim GH, Halder D, Park J, Namkung W, Shin I. Imidazole-based small molecules that promote neurogenesis in pluripotent cells. Angew Chem Int Ed Engl. 2014 Aug 25;53(35):9271-4. doi: 10.1002/anie.201404871. Epub 2014 Jul 9. PubMed PMID: 25044422.

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