FzM1.8


Catalog No. size PriceQuantity
M6958-2 2mg solid $111
M6958-10 10mg solid $452

Description

Cas:2204290-85-5

Product Information:

FzM1.8 is an allosteric agonist of the Frizzled receptor FZD4.

 

Chemical Formula: C18H14N2O4

 

Exact Mass: 322.0954

 

Molecular Weight: 322.32

 

Elemental Analysis: C, 67.08; H, 4.38; N, 8.69; O, 19.85

 

Chemical Name:

3-Hydroxy-5-(3-(naphthalen-2-yl)ureido)benzoic acid

 

InChi Key:

XGNNCRZDDAJBFU-UHFFFAOYSA-N

 

InChi Code: 

InChI=1S/C18H14N2O4/c21-16-9-13(17(22)23)8-15(10-16)20-18(24)19-14-6-5-11-3-1-2-4-12(11)7-14/h1-10,21H,(H,22,23)(H2,19,20,24)

 

Smiles Code:

O=C(O)C1=CC(NC(NC2=CC=C3C=CC=CC3=C2)=O)=CC(O)=C1

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

 

 

References:

 

  1. Riccio G, Bottone S, La Regina G, Badolati N, Passacantilli S, Rossi GB, Accardo A, Dentice M, Silvestri R, Novellino E, Stornaiuolo M. A Negative Allosteric Modulator of WNT Receptor Frizzled 4 Switches into an Allosteric Agonist. Biochemistry. 2018 Feb 6;57(5):839-851. doi: 10.1021/acs.biochem.7b01087. Epub 2018 Jan 19. PubMed PMID: 29293331.

 

Products are for research use only. Not for human use.

 

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