Hematein


Catalog No. size PriceQuantity
M6960-2 2mg solid $82
M6960-10 10mg solid $328

Description

Cas:475-25-2

Product Information:

Hematein, also known as Haematein, is an oxidized derivative of Hematoxylin (Haematoxylin) used in staining the staining of cell nuclei in animal tissue. Hematein also can be used in the staining of myelin sheaths and nerve fibers.

 

Chemical Formula: C16H12O6

 

Exact Mass: 300.0634

 

Molecular Weight: 300.266

 

Elemental Analysis: C, 64.00; H, 4.03; O, 31.97

 

Related CAS #: 475-25-2 (Hematein)   517-28-2 (Hematoxylin)  

 

Synonym:

 

Haematein

Hematoxylin

Haematoxylin

AI3-63013

NSC 7333

Chemical Name: 

3,4,6a,10-tetrahydroxy-6a,7-dihydroindeno[2,1-c]chromen-9(6H)-one

 

InChi Key:

HLUCICHZHWJHLL-UHFFFAOYSA-N

 

InChi Code: 

InChI=1S/C16H12O6/c17-10-2-1-8-13-9-4-12(19)11(18)3-7(9)5-16(13,21)6-22-15(8)14(10)20/h1-4,17,19-21H,5-6H2

 

Smiles Code:

O=C1C=C2CC3(O)C(C4=CC=C(O)C(O)=C4OC3)=C2C=C1O

 

 

Technical Data:

 

Appearance: Light brown to brown solid powder.

Purity: CORRESPONDS TO STANDARD

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

In Vitro:

Hematein (10-100 μM; 14 days) inhibits cells growth in A427 lung cancer cells.

Hematein (50 and 100 μM; 48 hours) induces apoptosis in A427 lung cancer cells.

Hematein (50 and 100 μM; 48 hours) inhibits CK2-specific Akt phosphorylation.

 

In Vivo:

Hematein (intraperitoneal injections; 50 mg/kg; twice a week for 6 weeks) inhibits tumor growth in A427 lung cancer cell xenografts.

 

 

References:

 

  1. Panayotacopoulou MT, Boukis D, Issidorides MR. Localization of phospholipids in human catecholamine neurons with Baker's acid haematein. J Neurocytol. 1989 Oct;18(5):593-7. PubMed PMID: 2482342.

 

  1. Elleder M, Lojda Z. Studies in lipid histochemistry. II. The nature of the material stained with acid haematein test and with OTAN reaction in red blood cells. Histochemie. 1970;24(1):21-8. PubMed PMID: 4098193.

 

  1. Roozemond RC. A comparison of the Baker acid Haematein staining of selected regions of rat hypothalamus with the fatty acid composition of their phosphatidyl choline content and their polar lipid fraction as determined by gas liquid chromatography. Histochem J. 1970 May;2(3):219-30. PubMed PMID: 4112993.

 

  1. CAIN AJ. An examination of Baker's acid haematein test for phospholipines. Q J Microsc Sci. 1947 Dec;88(Pt 4):467-78. PubMed PMID: 18904463.

 

  1. LANE NJ. VISUALIZATION OF SITES OF PHOSPHATASE ACTIVITIES BY MEANS OF MORDANTED HAEMATEIN. J Histochem Cytochem. 1965 Mar;13:235-8. PubMed PMID: 14327696.

 

Products are for research use only. Not for human use.

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