Description
SIS17 is a potent and selective HDAC 11 inhibitor with an IC50 value of 0.83 μM. SIS17, is active in cells and inhibited the demyristoylation of a known HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs.
Product information
CAS Number: 2374313-54-7
Molecular Weight: 366.60
Formula: C21H38N2OS
Synonym:
SIS-17
SIS 17
SIS17
Chemical Name: N'-hexadecylthiophene-2-carbohydrazide
Smiles: CCCCCCCCCCCCCCCCNNC(=O)C1=CC=CS1
InChiKey: HSHXDCVZWHOWCS-UHFFFAOYSA-N
InChi: InChI=1S/C21H38N2OS/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18-22-23-21(24)20-17-16-19-25-20/h16-17,19,22H,2-15,18H2,1H3,(H,23,24)
Technical Data
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
References:
- Son SI, Cao J, Zhu CL, Miller SP, Lin H. Activity-Guided Design ofHDAC11-Specific Inhibitors. ACS Chem Biol. 2019 Jul 19;14(7):1393-1397. doi:10.1021/acschembio.9b00292. Epub 2019 Jul 2. PubMed PMID: 31264832.
Products are for research use only. Not for human use.
Payment & Security
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.