Catalog No. size PriceQuantity
M6973-2 2mg solid $108
M6973-10 10mg solid $452


DUN09716 is KRAS inhibitor with potential antitumor activity. DUN09716 was reported inn patent US 9884046.

Product information

CAS Number: 300809-71-6

Molecular Weight: 292.81

Formula: C13H9ClN2S2



DUN 09716

Chemical Name: 4-[(Benzo[d]thiazol-2-yl)thio]-3-chloroaniline

Smiles: NC1=CC(Cl)=C(C=C1)SC1=NC2=CC=CC=C2S1


InChi: InChI=1S/C13H9ClN2S2/c14-9-7-8(15)5-6-11(9)17-13-16-10-3-1-2-4-12(10)18-13/h1-7H,15H2

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 250 mg/mL (853.80 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

DUN09716 bound to KRASG12D, KRAS G12C and KRAS Q61H protein with a moderate binding affinity of -5.38, -5.41, and -3.97 kcal/mol, respectively. DUN09716 (0-100 μM) shows strong inhibition selectivity in NSCLC cells with IC50s ranging from 39.56 to 66.02 μM for H2122, H358 and H460 cells (at 72 hours). DUN09716 (0-100 μM; 24 hours) blocks GTP-KRAS formation in H2122, H358 and H460 cells. DUN09716 (25-100 μM; 48 hours) inhibits the activation of KRAS downstream signaling pathway. DUN09716 (0-100 μM; 24-72 hours) induces cell cycle arrest and apoptosis in NSCLC.


  1. Xie C, et al. Identification of a New Potent Inhibitor Targeting KRAS in Non-small Cell Lung Cancer Cells. Front Pharmacol. 2017;8:823. Published 2017 Nov 14.

Products are for research use only. Not for human use.

Payment & Security

PayPal Venmo

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed