CUN25391


Catalog No. size PriceQuantity
M6986-2 2mg solid $108
M6986-10 10mg solid $441

Description

Cas:105925-39-1

Product Information

CUN25391, also known as Tubulin inhibitor 6 or iHAP1 (Compound 14b in literature 1) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. CUN25391 inhibits tubulin polymerization with an IC50 of 0.87 μM. CUN25391 has CAS#105925-39-1, no formal name. For the convenience of scientific communication, we named it as CUN25391(combined from Inchi key plus CAS#) according to Hodoodo Chemical Nomenclature (https://hodoodo.com/hodoodo-chemical-nomenclature).

 

Chemical Formula: C20H14ClNO2S

 

Exact Mass: 367.0434

 

Molecular Weight: 367.847

 

Elemental Analysis: C, 65.30; H, 3.84; Cl, 9.64; N, 3.81; O, 8.70; S, 8.72

 

Synonym:

 

Tubulin inhibitor 6

CUN25391

CUN-25391

CUN 25391

iHAP1

 

Chemical Name:

(2-chloro-10H-phenothiazin-10-yl)(4-methoxyphenyl)methanone

 

InChi Key:

CSWHYHPUEDNIQY-UHFFFAOYSA-N

 

InChi Code: InChI=1S/C20H14ClNO2S/c1-24-15-9-6-13(7-10-15)20(23)22-16-4-2-3-5-18(16)25-19-11-8-14(21)12-17(19)22/h2-12H,1H3

 

Technical Data:

O=C(N1C2=C(C=CC=C2)SC3=CC=C(Cl)C=C13)C4=CC=C(OC)C=C4

 

 

In Vitro:

Tubulin inhibitor 6 displays submicromolar antiproliferative activity.

 

 

References

 

  1. Prinz H, et al. N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem. 2011 Jun 23;54(12):4247-63.

 

Products are for research use only. Not for human use.

 

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