CUN25391, also known as Tubulin inhibitor 6 or iHAP1 (Compound 14b in literature 1) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. CUN25391 inhibits tubulin polymerization with an IC50 of 0.87 μM. CUN25391 has CAS#105925-39-1, no formal name. For the convenience of scientific communication, we named it as CUN25391(combined from Inchi key plus CAS#) according to Hodoodo Chemical Nomenclature (https://hodoodo.com/hodoodo-chemical-nomenclature).
CAS Number: 105925-39-1
Molecular Weight: 367.85
Tubulin inhibitor 6
Chemical Name: (2-chloro-10H-phenothiazin-10-yl)(4-methoxyphenyl)methanone
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
Tubulin inhibitor 6 displays submicromolar antiproliferative activity.
- Prinz H, et al. N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem. 2011 Jun 23;54(12):4247-63.
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