Hydromethylthionine, also known as LMTM and Leucomethylene Blue, is a apotent tau aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. Hydromethylthionine showed pharmacological activity on brain structure and function as both monotherapy and as an add-on to symptomatic treatment in certain patients with Alzheimer’s disease.
CAS Number: 951131-15-0
Molecular Weight: 447.23
Leucomethylene Blue dihydrobromide
Leukomethylene Blue dihydrobromide
Reduced methylene Blue dihydrobromide
Chemical Name: N3,N3,N7,N7-Tetramethyl-10H-phenothiazine-3,7-diamine dihydrobromide
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
- Hashweh NN, Bartochowski Z, Khoury R, Grossberg GT. An evaluation of hydromethylthionine as a treatment option for Alzheimer's disease. Expert Opin Pharmacother. 2020 Apr;21(6):619-627. doi: 10.1080/14656566.2020.1719066. Epub 2020 Feb 8. PMID: 32037892.
- Lee HE, Lim D, Lee JY, Lim SM, Pae AN. Recent tau-targeted clinical strategies for the treatment of Alzheimer's disease. Future Med Chem. 2019 Aug;11(15):1845-1848. doi: 10.4155/fmc-2019-0151. PMID: 31517533.
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