Hydromethylthionine HBr


Catalog No. size PriceQuantity
M6987-2 2mg solid $111
M6987-10 10mg solid $436

Description

Hydromethylthionine, also known as LMTM and Leucomethylene Blue, is a apotent tau aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. Hydromethylthionine showed pharmacological activity on brain structure and function as both monotherapy and as an add-on to symptomatic treatment in certain patients with Alzheimer’s disease.

Product information

CAS Number: 951131-15-0

Molecular Weight: 447.23

Formula: C16H21Br2N3S

Synonym:

TRX-0237 HBr

TRX-0237 dihydrobromide

TRX0237

Hydromethylthionine HBr

TRX 0237

Leucomethylene Blue dihydrobromide

Leukomethylene Blue dihydrobromide

Reduced methylene Blue dihydrobromide

Chemical Name: N3,N3,N7,N7-Tetramethyl-10H-phenothiazine-3,7-diamine dihydrobromide

Smiles: Br.Br.CN(C)C1=CC2SC3=CC(=CC=C3NC=2C=C1)N(C)C

InChiKey: JAUPSVVTGFBHTN-UHFFFAOYSA-N

InChi: InChI=1S/C16H19N3S.2BrH/c1-18(2)11-5-7-13-15(9-11)20-16-10-12(19(3)4)6-8-14(16)17-13;;/h5-10,17H,1-4H3;2*1H

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

References:

  1. Hashweh NN, Bartochowski Z, Khoury R, Grossberg GT. An evaluation of hydromethylthionine as a treatment option for Alzheimer's disease. Expert Opin Pharmacother. 2020 Apr;21(6):619-627. doi: 10.1080/14656566.2020.1719066. Epub 2020 Feb 8. PMID: 32037892.
  2. Lee HE, Lim D, Lee JY, Lim SM, Pae AN. Recent tau-targeted clinical strategies for the treatment of Alzheimer's disease. Future Med Chem. 2019 Aug;11(15):1845-1848. doi: 10.4155/fmc-2019-0151. PMID: 31517533.

Products are for research use only. Not for human use.

Payment & Security

American Express Diners Club Discover JCB Mastercard PayPal Venmo Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed