Hydromethylthionine HBr

Catalog No. size PriceQuantity
M6987-2 2mg solid $111
M6987-10 10mg solid $436


Hydromethylthionine, also known as LMTM and Leucomethylene Blue, is a apotent tau aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. Hydromethylthionine showed pharmacological activity on brain structure and function as both monotherapy and as an add-on to symptomatic treatment in certain patients with Alzheimer’s disease.

Product information

CAS Number: 951131-15-0

Molecular Weight: 447.23

Formula: C16H21Br2N3S


TRX-0237 HBr

TRX-0237 dihydrobromide


Hydromethylthionine HBr

TRX 0237

Leucomethylene Blue dihydrobromide

Leukomethylene Blue dihydrobromide

Reduced methylene Blue dihydrobromide

Chemical Name: N3,N3,N7,N7-Tetramethyl-10H-phenothiazine-3,7-diamine dihydrobromide

Smiles: Br.Br.CN(C)C1=CC2SC3=CC(=CC=C3NC=2C=C1)N(C)C


InChi: InChI=1S/C16H19N3S.2BrH/c1-18(2)11-5-7-13-15(9-11)20-16-10-12(19(3)4)6-8-14(16)17-13;;/h5-10,17H,1-4H3;2*1H

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200


  1. Hashweh NN, Bartochowski Z, Khoury R, Grossberg GT. An evaluation of hydromethylthionine as a treatment option for Alzheimer's disease. Expert Opin Pharmacother. 2020 Apr;21(6):619-627. doi: 10.1080/14656566.2020.1719066. Epub 2020 Feb 8. PMID: 32037892.
  2. Lee HE, Lim D, Lee JY, Lim SM, Pae AN. Recent tau-targeted clinical strategies for the treatment of Alzheimer's disease. Future Med Chem. 2019 Aug;11(15):1845-1848. doi: 10.4155/fmc-2019-0151. PMID: 31517533.

Products are for research use only. Not for human use.

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