Catalog No. size PriceQuantity
M6993-2 2mg solid $98
M6993-10 10mg solid $401



Product Information

Z433927330 is a potent and selective aquaporin-7 (AQP7) inhibitor. Z433927330 is also a partial AQP3 inhibitor (IC50, ∼0.7-0.9 μm) and a potent and efficacious inhibitor of mouse AQP7 water permeability (IC50, ∼0.2 μm). Moreover, Z433927330 blocked aquaglyceroporin H2O2 permeability.


Chemical Formula: C20H20N4O3


Exact Mass: 364.1535


Molecular Weight: 364.405


Elemental Analysis: Chemical Formula: Exact Mass: Elemental Analysis: C, 65.92; H, 5.53; N, 15.38; O, 13.17






Z 433927330


Chemical Name:

ethyl 4-(3-(4-(1H-pyrazol-1-yl)benzyl)ureido)benzoate


InChi Key:



InChi Code: InChI=1S/C20H20N4O3/c1-2-27-19(25)16-6-8-17(9-7-16)23-20(26)21-14-15-4-10-18(11-5-15)24-13-3-12-22-24/h3-13H,2,14H2,1H3,(H2,21,23,26)


Smiles Code:




Technical Data:


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


In Vitro:

Z433927330 inhibits glycerol permeability, with an IC50 of ~0.6 µM.





  1. Sonntag Y, Gena P, Maggio A, Singh T, Artner I, Oklinski MK, Johanson U, Kjellbom P, Nieland JD, Nielsen S, Calamita G, Rützler M. Identification and characterization of potent and selective aquaporin-3 and aquaporin-7 inhibitors. J Biol Chem. 2019 May 3;294(18):7377-7387. doi: 10.1074/jbc.RA118.006083. Epub 2019 Mar 11. PMID: 30862673; PMCID: PMC6509502.


Products are for research use only. Not for human use.


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