Z433927330 is a potent and selective aquaporin-7 (AQP7) inhibitor. Z433927330 is also a partial AQP3 inhibitor (IC50, ∼0.7-0.9 μm) and a potent and efficacious inhibitor of mouse AQP7 water permeability (IC50, ∼0.2 μm). Moreover, Z433927330 blocked aquaglyceroporin H2O2 permeability.
Chemical Formula: C20H20N4O3
Exact Mass: 364.1535
Molecular Weight: 364.405
Elemental Analysis: Chemical Formula: Exact Mass: Elemental Analysis: C, 65.92; H, 5.53; N, 15.38; O, 13.17
InChi Code: InChI=1S/C20H20N4O3/c1-2-27-19(25)16-6-8-17(9-7-16)23-20(26)21-14-15-4-10-18(11-5-15)24-13-3-12-22-24/h3-13H,2,14H2,1H3,(H2,21,23,26)
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
Z433927330 inhibits glycerol permeability, with an IC50 of ~0.6 µM.
Sonntag Y, Gena P, Maggio A, Singh T, Artner I, Oklinski MK, Johanson U, Kjellbom P, Nieland JD, Nielsen S, Calamita G, Rützler M. Identification and characterization of potent and selective aquaporin-3 and aquaporin-7 inhibitors. J Biol Chem. 2019 May 3;294(18):7377-7387. doi: 10.1074/jbc.RA118.006083. Epub 2019 Mar 11. PMID: 30862673; PMCID: PMC6509502.
Products are for research use only. Not for human use.
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