Z433927330 is a potent and selective aquaporin-7 (AQP7) inhibitor. Z433927330 is also a partial AQP3 inhibitor (IC50, ∼0.7-0.9 μm) and a potent and efficacious inhibitor of mouse AQP7 water permeability (IC50, ∼0.2 μm). Moreover, Z433927330 blocked aquaglyceroporin H2O2 permeability.
CAS Number: 1005883-72-6
Molecular Weight: 364.40
Chemical Name: ethyl 4-(3-(4-(1H-pyrazol-1-yl)benzyl)ureido)benzoate
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
How to use
Z433927330 inhibits glycerol permeability, with an IC50 of ~0.6 µM.
- Sonntag Y, Gena P, Maggio A, Singh T, Artner I, Oklinski MK, Johanson U, Kjellbom P, Nieland JD, Nielsen S, Calamita G, Rützler M. Identification and characterization of potent and selective aquaporin-3 and aquaporin-7 inhibitors. J Biol Chem. 2019 May 3;294(18):7377-7387. doi: 10.1074/jbc.RA118.006083. Epub 2019 Mar 11. PMID: 30862673; PMCID: PMC6509502.
Products are for research use only. Not for human use.
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