LC3-mHTT-IN-AN1

Cas：486443-73-6

Product Information：

LC3-mHTT-IN-AN1 is a HTT-LC3 linker compound. LC3-mHTT-IN-AN1 interacts with both LC3 and mHTT, but not with the wild-type HTT protein. LC3-mHTT-IN-AN1 reduced mHTT levels in an allele-selective manner, and rescued disease-relevant phenotypes in cells and in vivo in fly and mouse models of Huntington's disease.

Chemical Formula: C15H9Br2NO3

Exact Mass: 408.8949

Molecular Weight: 411.049

Elemental Analysis: C, 43.83; H, 2.21; Br, 38.88; N, 3.41; O, 11.68

Synonyms:

486443-73-6

LC3-mHTT-IN-1

EX-A4041

ZINC2104376

STK521330

AKOS000355497

HY-130258

CS-0106127

5-Bromo-3-(3-bromo-4,5-dihydroxybenzylidene)indolin-2-one

(3Z)-5-bromo-3-(3-bromo-4,5-dihydroxybenzylidene)-1,3-dihydro-2H-indol-2-one

Chemical Name:

(Z)-5-bromo-3-(3-bromo-4,5-dihydroxybenzylidene)indolin-2-one

InChi Key:

GPKLWRHHVIBYEO-KMKOMSMNSA-N

InChi Code: InChI=1S/C15H9Br2NO3/c16-8-1-2-12-9(6-8)10(15(21)18-12)3-7-4-11(17)14(20)13(19)5-7/h1-6,19-20H,(H,18,21)/b10-3-

Smiles Code:

BrC1=CC=C(C/2=C1)NC(C2=C/C3=CC(Br)=C(C(O)=C3)O)=O

Technical Data：

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

In Vitro:

LC3-mHTT-IN-AN1 (10, 50, 100, and 300 nM) reduces the levels of mHTT in an allele-selective manner in cultured HD mouse neurons.

References：

1. Li Z, Wang C, Wang Z, Zhu C, Li J, Sha T, Ma L, Gao C, Yang Y, Sun Y, Wang J, Sun X, Lu C, Difiglia M, Mei Y, Ding C, Luo S, Dang Y, Ding Y, Fei Y, Lu B. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Nov;575(7781):203-209. doi: 10.1038/s41586-019-1722-1. Epub 2019 Oct 30. PMID: 31666698.

Products are for research use only. Not for human use.