Description
LC3-mHTT-IN-AN1 is a HTT-LC3 linker compound. LC3-mHTT-IN-AN1 interacts with both LC3 and mHTT, but not with the wild-type HTT protein. LC3-mHTT-IN-AN1 reduced mHTT levels in an allele-selective manner, and rescued disease-relevant phenotypes in cells and in vivo in fly and mouse models of Huntington's disease
Product information
CAS Number: 486443-73-6
Molecular Weight: 411.04
Formula: C15H9Br2NO3
Synonym:
LC3-mHTT-IN-1
EX-A4041
HY-130258
486443-73-6
ZINC2104376
STK521330
AKOS000355497
CS-0106127
5-Bromo-3-(3-bromo-4,5-dihydroxybenzylidene)indolin-2-one
(3Z)-5-bromo-3-(3-bromo-4,5-dihydroxybenzylidene)-1,3-dihydro-2H-indol-2-one
(Z)-5-bromo-3-(3-bromo-4,5-dihydroxybenzylidene)indolin-2-one
Chemical Name: (Z)-5-bromo-3-(3-bromo-4,5-dihydroxybenzylidene)indolin-2-one
Smiles: OC1=CC(/C=C2\C(=O)NC3=CC=C(Br)C=C3\2)=CC(Br)=C1O
InChiKey: GPKLWRHHVIBYEO-KMKOMSMNSA-N
InChi: InChI=1S/C15H9Br2NO3/c16-8-1-2-12-9(6-8)10(15(21)18-12)3-7-4-11(17)14(20)13(19)5-7/h1-6,19-20H,(H,18,21)/b10-3-
Technical Data
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
How to use
In Vitro:
LC3-mHTT-IN-AN1 (10, 50, 100, and 300 nM) reduces the levels of mHTT in an allele-selective manner in cultured HD mouse neurons.
References:
- Li Z, Wang C, Wang Z, Zhu C, Li J, Sha T, Ma L, Gao C, Yang Y, Sun Y, Wang J, Sun X, Lu C, Difiglia M, Mei Y, Ding C, Luo S, Dang Y, Ding Y, Fei Y, Lu B. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Nov;575(7781):203-209. doi: 10.1038/s41586-019-1722-1. Epub 2019 Oct 30. PMID: 31666698.
Products are for research use only. Not for human use.
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