SJA710-6

Cas：1397255-09-2

Product Information：

SJA710-6 is a Hepatic Differentiation Inducer which is able to induce the differentiation of rat MSCs (rMSCs) toward hepatocyte-like cells in vitro, where rMSCs treated with SJA710-6 have typical morphological and functional characteristics of hepatic cells, including glycogen storage, urea secretion, uptake of low density lipoprotein (LDL) and expression of hepatocyte-specific genes and proteins. Expression of FoxH1 (FAST1/2) induces the differentiation of rMSCs towards hepatocyte-like cells, suggesting that this gene plays an important role in the hepatic fate specification of rMSCs.

Chemical Formula: C22H20BrFN4

Exact Mass: 438.0855

Molecular Weight: 439.3324

Elemental Analysis: C, 60.15; H, 4.59; Br, 18.19; F, 4.32; N, 12.75

Synonym:

SJA710-6

SJA-710-6

SJA 710-6

SJA7106

SJA-7106

SJA 7106

Chemical Name: 2-(4-Bromophenyl)-N-(4-fluorobenzyl)-3-propyl-3H-imidazo[4,5-b]pyridin-5-amine

InChi Key: 

RPNQWWSSADJSGS-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H20BrFN4/c1-2-13-28-21(16-5-7-17(23)8-6-16)26-19-11-12-20(27-22(19)28)25-14-15-3-9-18(24)10-4-15/h3-12H,2,13-14H2,1H3,(H,25,27)

Smiles Code:

CCCN1C(C2=CC=C(Br)C=C2)=NC3=CC=C(NCC4=CC=C(F)C=C4)N=C31

Technical Data：

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

References：

1. Ouyang J, Shao J, Zou H, Lou Y, Yu Y. Hepatic differentiation of rat mesenchymal stem cells by a small molecule. ChemMedChem. 2012 Aug;7(8):1447-52. doi: 10.1002/cmdc.201200162. Epub 2012 Jun 19. PMID: 22715131.

Products are for research use only. Not for human use.