DMU-2105


Catalog No. size PriceQuantity
M7005-2 2mg solid $88
M7005-10 10mg solid $356

Description

Cas:1031063-36-1

Product Information

DMU-2105 is a potent and selective CYP1B1 inhibitor with IC50s of 10 nM and 742 nM for CYP1B1 and CYP1A1, respectively. DMU-2105 showed a very high level of selectivity towards CYP1B1 with respect to the IC50 values obtained with CYP1A1, CYP1A2, CYP3A4, CYP2D6, CYP2C9 and CYP2C19 Sacchrosome.

 

Chemical Formula: C18H13NO

 

Exact Mass: 259.0997

 

Molecular Weight: 259.308

 

Elemental Analysis: C, 83.37; H, 5.05; N, 5.40; O, 6.17

 

Synonym:

 

DMU-2105

DMU 2105

DMU2105

 

Chemical Name: 

3-(2-Naphthalenyl)-1-(3-pyridinyl)-2-propen-1-one

 

InChi Key: 

VWBDGXJRQZDLRV-CSKARUKUSA-N

 

InChi Code: InChI=1S/C18H13NO/c20-18(17-6-3-11-19-13-17)10-8-14-7-9-15-4-1-2-5-16(15)12-14/h1-13H/b10-8+

 

Smiles Code:

O=C(C1=CC=CN=C1)/C=C/C2=CC=C3C=CC=CC3=C2

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

 

References

 

  1. Horley NJ, Beresford KJ, Chawla T, McCann GJ, Ruparelia KC, Gatchie L, Sonawane VR, Williams IS, Tan HL, Joshi P, Bharate SS, Kumar V, Bharate SB, Chaudhuri B. Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines. Eur J Med Chem. 2017 Mar 31;129:159-174. doi: 10.1016/j.ejmech.2017.02.016. Epub 2017 Feb 9. PMID: 28222316.

 

Products are for research use only. Not for human use.

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