BAY-1251152 racemate


Catalog No. size PriceQuantity
M7011-2 2mg solid $100
M7011-10 10mg solid $310

Description

BAY-1251152 racemate, also known as (±)-BAY-1251152, is a racemic mixture of BAY-1251152. BAY-1251152 is a potent and highly selective PTEF/CDK9 inhibitor. BAY1251152 binds to and blocks the phosphorylation and kinase activity of CDK9, thereby preventing PTEFb-mediated activation of RNA Pol II and leading to the inhibition of gene transcription of various anti-apoptotic proteins. This may cause cell cycle arrest and induce apoptosis, which may lead to a reduction in tumor cell proliferation.

Product information

CAS Number: 1610358-53-6

Molecular Weight: 404.43

Formula: C19H18F2N4O2S

Synonym:

BAY-1251152 racemate

BAY1251152

BAY 1251152

(±)-BAY-1251152

((2-((5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)amino)pyridin-4-yl)methyl)(imino)(methyl)-l6-sulfanone

Related CAS Number:

1610358-56-9 ((+)​BAY-1251152)

1610358-59-2 ((-​)​BAY-1251152)

1610368-59-6 ((R)BAY-1251152 HCl)

1610408-96-2 ((R)BAY-1251152)

1610408-97-3 ((S)(R)BAY-1251152)

1610368-60-9 ((S)BAY-1251152 HCl)

Chemical Name: 2-Pyridinamine, 5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-[4-[(S-methylsulfonimidoyl)methyl]-2-pyridinyl]-

Smiles: COC1=CC(F)=CC=C1C1=CC(NC2=CC(CS(C)(=N)=O)=CC=N2)=NC=C1F

InChiKey: YZCUMZWULWOUMD-UHFFFAOYSA-N

InChi: InChI=1S/C19H18F2N4O2S/c1-27-17-8-13(20)3-4-14(17)15-9-19(24-10-16(15)21)25-18-7-12(5-6-23-18)11-28(2,22)26/h3-10,22H,11H2,1-2H3,(H,23,24,25)

Technical Data

Appearance: Solid powder

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 50mg/mL

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0-4oC for short term (days to weeks) or -20oC for long term (months to years).

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0-4oC for short term (days to weeks), or -20oC for long term (months).

Drug Formulation: This drug may be formulated in DMSO

HS Tariff Code: 2934.99.9001

References:

  1. Luecking, et al. Identification of potent and highly selective PTEFb inhibitor BAY 1251152 for the treatment of cancer: from p.o. to i.v. application via scaffold hops [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 984. doi:10.1158/1538-7445.AM2017-984.

Products are for research use only. Not for human use.

Payment & Security

PayPal Venmo

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed