MVN38807


Catalog No. size PriceQuantity
M7018-2 2mg solid $107
M7018-10 10mg solid $447

Description

Cas:2379438-80-7

Product Information

MVN38807, also known as Y-1, is neuraminidase (NA) inhibitor used in preparation of drugs for resisting H1N1 influenza virus. Y-1 exerts the best inhibition activity (IC50 = 0.21 μM) against NA, which is better than oseltamivir carboxylate (OSC) (IC50 = 3.04 μM) and lead AN-329/10738021 (IC50 = 1.92 μM). MVN38807 has CAS#2379438-80-7, no formal name. For the convenience of scientific communication, we named it as MVN38807 (combined from Inchi key plus CAS#) according to Hodoodo Chemical Nomenclature (https://hodoodo.com/hodoodo-chemical-nomenclature).

 

Chemical Formula: C14H11N3O6

 

Exact Mass: 317.0648

 

Molecular Weight: 317.257

 

Elemental Analysis: C, 53.00; H, 3.49; N, 13.25; O, 30.26

 

Synonym: 

 

Y-1

Y1

Y 1

MVN38807

MVN-38807

MVN 38807

 

Chemical Name:

Benzoic acid, 3,5-dihydroxy-, (2E)-2-[(4-hydroxy-3-nitrophenyl)methylene]hydrazide

 

InChi Key: 

MCGROFKAAXXTBN-VIZOYTHASA-N

 

InChi Code: InChI=1S/C14H11N3O6/c18-10-4-9(5-11(19)6-10)14(21)16-15-7-8-1-2-13(20)12(3-8)17(22)23/h1-7,18-20H,(H,16,21)/b15-7+

 

Smiles Code:

O=C(N/N=C/C1=CC=C(O)C([N+]([O-])=O)=C1)C2=CC(O)=CC(O)=C2

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

In Vitro:

Neuraminidase-IN-1 has excellent activity against H1N1 influenza virus, has completely different structure from previous neuraminidase, has good inhibitory effect on the A/WSN/33H1N1 virus strains, and has low toxicity and good druggability.

 

 

References

 

  1. Yu R, Cheng LP, Li M, Pang W. Discovery of Novel Neuraminidase Inhibitors by Structure-Based Virtual Screening, Structural Optimization, and Bioassay. ACS Med Chem Lett. 2019 Nov 25;10(12):1667-1673. doi: 10.1021/acsmedchemlett.9b00447. PMID: 31857844; PMCID: PMC6912870.

 

Products are for research use only. Not for human use.

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