MVN38807

MVN38807, also known as Y-1, is neuraminidase (NA) inhibitor used in preparation of drugs for resisting H1N1 influenza virus. Y-1 exerts the best inhibition activity (IC50 = 0.21 μM) against NA, which is better than oseltamivir carboxylate (OSC) (IC50 = 3.04 μM) and lead AN-329/10738021 (IC50 = 1.92 μM). This product has not formal name. For the convenience of scientific communication, we named it by combining its Inchi key (3 letters from the first letter of each section) with the last 5 digits of its CAS number or its molecule weight if its CAS number is not available (see MedKoo Chemical Nomenclature, https://www.medkoo.com/page/naming).

Product information

CAS Number: 2379438-80-7

Molecular Weight: 317.25

Formula: C14H11N3O6

Synonym:

Y-1

MVN-38807

Chemical Name: Benzoic acid, 3,5-dihydroxy-, (2E)-2-[(4-hydroxy-3-nitrophenyl)methylene]hydrazide

Smiles: [O-][N+](=O)C1=CC(/C=N/NC(=O)C2C=C(O)C=C(O)C=2)=CC=C1O

InChiKey: MCGROFKAAXXTBN-VIZOYTHASA-N

InChi: InChI=1S/C14H11N3O6/c18-10-4-9(5-11(19)6-10)14(21)16-15-7-8-1-2-13(20)12(3-8)17(22)23/h1-7,18-20H,(H,16,21)/b15-7+

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

Neuraminidase-IN-1 has excellent activity against H1N1 influenza virus, has completely different structure from previous neuraminidase, has good inhibitory effect on the A/WSN/33H1N1 virus strains, and has low toxicity and good druggability.

References:

1. Yu R, Cheng LP, Li M, Pang W. Discovery of Novel Neuraminidase Inhibitors by Structure-Based Virtual Screening, Structural Optimization, and Bioassay. ACS Med Chem Lett. 2019 Nov 25;10(12):1667-1673. doi: 10.1021/acsmedchemlett.9b00447. PMID: 31857844; PMCID: PMC6912870.

Products are for research use only. Not for human use.