BCI inhibitor


Catalog No. size PriceQuantity
M7019-2 2mg solid $120
M7019-10 10mg solid $476

Description

Cas:1245792-51-1

Product Information

BCI is an allosteric inhibitor of dual specificity phosphatase (DUSP). BCI specifically inhibits DUSP6 and DUSP1 with EC50s of 13.3 and 8.0 μM in cells, respectively

 

Chemical Formula: C22H23NO

 

Exact Mass: 317.178

 

Molecular Weight: 317.432

 

Elemental Analysis: C, 83.24; H, 7.30; N, 4.41; O, 5.04

 

Synonym:

 

BCI

  • -BCI

  • BCI inhibitor

 

Chemical Name: (E)-2-benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one

 

InChi Key:

XJDKPLZUXCIMIS-HMMYKYKNSA-N

 

InChi Code: InChI=1S/C22H23NO/c24-22-19-14-8-7-13-18(19)21(23-17-11-5-2-6-12-17)20(22)15-16-9-3-1-4-10-16/h1,3-4,7-10,13-15,17,21,23H,2,5-6,11-12H2/b20-15+

 

Smiles Code:

O=C1/C(C(C2=C1C=CC=C2)NC3CCCCC3)=C/C4=CC=CC=C4

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

 

References

 

  1. Korotchenko VN, et al. In vivo structure-activity relationship studies support allosteric targeting of a dual specificity phosphatase. Chembiochem. 2014 Jul 7;15(10):1436-45.

 

Products are for research use only. Not for human use.

 

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