Flutamide


Catalog No. size PriceQuantity
M7030-2 2mg solid $77
M7030-10 10mg solid $320

Description

Cas:13311-84-7

Product Information

Flutamide, also known as SCH13521, is a toluidine derivative and nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more potent active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone binding at androgen receptors, forming inactive complexes which cannot translocate into the cell nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest or transient tumor regression. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

 

Chemical Formula: C11H11F3N2O3

 

Exact Mass: 276.07218

 

Molecular Weight: 276.21

 

Elemental Analysis: C, 47.83; H, 4.01; F, 20.63; N, 10.14; O, 17.38

 

Synonym:

 

SCH13521    

SCH-13521   

SCH 13521   

Flucinom   

Flugerel

Niftolid       

Eulexin      

Apimid      

Chimax     

Drogenil

Euflex        

Eulexine     

Flucinome    

Fluken      

Flulem

Flutabene     

Flutacan

FlutaGry

Flutamex

Flutamin

Flutan

Flutaplex

Fugerel

Grisetin

Oncosal

Profamid

Prostacur

Prostadirex

Prostica

Prostogenat

Tafenil

Tecnoflut

Testotard

FLUT

 

Chemical Name:

N-(4-nitro-3-(trifluoromethyl)phenyl)isobutyramide

 

InChi Key:

MKXKFYHWDHIYRV-UHFFFAOYSA-N

 

InChi Code: InChI=1S/C11H11F3N2O3/c1-6(2)10(17)15-7-3-4-9(16(18)19)8(5-7)11(12,13)14/h3-6H,1-2H3,(H,15,17)

 

Smiles Code:

CC(C)C(NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1)=O

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

 

References

 

  1. Simard J, et al. Characteristics of interaction of the antiandrogen flutamide with the androgen receptor in various target tissues. Mol Cell Endocrinol. 1986 Mar;44(3):261-70.

 

  1. Luthy IA, et al. Androgenic activity of synthetic progestins and spironolactone in androgen-sensitive mouse mammary carcinoma (Shionogi) cells in culture. J Steroid Biochem. 1988 Nov;31(5):845-52.

 

  1. Crawford ED, et al. A controlled trial of leuprolide with and without flutamide in prostatic carcinoma. N Engl J Med. 1989 Aug 17;321(7):419-24.

 

  1. Marchetti B, et al. Characteristics of flutamide action on prostatic and testicular functions in the rat. J Steroid Biochem. 1988 Jun;29(6):691-8.

 

Products are for research use only. Not for human use.

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