Catalog No. size PriceQuantity
M7046-2 2mg solid $104
M7046-10 10mg solid $401


FG-7142 is a benzodiazepine receptor ligand with anxiogenic and proconvulsant properties.

Product information

CAS Number: 78538-74-6

Molecular Weight: 225.25

Formula: C13H11N3O




FG 7142

Chemical Name: N-methyl-9H-pyrido[3,4-b]indole-3-carboxamide

Smiles: CNC(=O)C1=CC2=C(C=N1)NC1=CC=CC=C21


InChi: InChI=1S/C13H11N3O/c1-14-13(17)11-6-9-8-4-2-3-5-10(8)16-12(9)7-15-11/h2-7,16H,1H3,(H,14,17)

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

FG-7142 has affinity for those expressing the α subunit, the Ki values are 91 nM; 330 nM; 492 nM and 2.150 μM for α1, α2, α3 and α5 subunits, respectively. FG-7142 has a high efficacy in modulating GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50 = 137 nM) as compared to the other α subunits (EC50: α2= 507 nM, α3=1.021μM , α5=1.439 μM).

In Vivo:

FG-7142 (intraperitoneal injection; 15-30 mg/kg) activates mesolimbocortical dopaminergic projections, leading to increases in dopamine in the prefrontal cortex and the nucleus accumbens in rats. FG-7142 (intraperitoneal injection; 15 mg/kg) increases tyrosine hydroxylase activity and dopamine turnover in the medial prefrontal cortex and ventral tegmentum in vivo, but effects are not detected in mesolimbic or nigrostriatal areas.


  1. Horowski R. FG 7142: is this validated tool to study anxiety now forgotten? J Neural Transm (Vienna). 2020 Feb;127(2):287-289. doi: 10.1007/s00702-019-02136-3. Epub 2020 Jan 11. PMID: 31927622.
  2. Kurumaji A, Nishikawa T. An anxiogenic drug, FG 7142, induced an increase in mRNA of Btg2 and Adamts1 in the hippocampus of adult mice. Behav Brain Funct. 2012 Aug 22;8:43. doi: 10.1186/1744-9081-8-43. PMID: 22913326; PMCID: PMC3541064.
  3. Martire SI, Parkes SL, Westbrook RF. The effects of FG 7142 on sensory- specific satiety in rats. Behav Brain Res. 2010 May 1;209(1):131-6. doi: 10.1016/j.bbr.2010.01.034. Epub 2010 Jan 29. PMID: 20117147.

Products are for research use only. Not for human use.

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