Diphenylterazine


Catalog No. size PriceQuantity
M7049-2 2mg solid $126
M7049-10 10mg solid $522

Description

Cas:344940-63-2

Product Information

Diphenylterazine is a bioluminescence agent. Diphenylterazine alone yields very little background, leading to excellent signal-to-background ratios.

 

Chemical Formula: C25H19N3O

 

Exact Mass: 377.1528

 

Molecular Weight: 377.447

 

Elemental Analysis: C, 79.55; H, 5.07; N, 11.13; O, 4.24

 

Synonym: Diphenylterazine; DTZ;

 

Chemical Name: 

2-benzyl-6,8-diphenylimidazo[1,2-a]pyrazin-3(7H)-one

 

InChi Key:

HYQVAZNNCBIZSK-UHFFFAOYSA-N

 

InChi Code: InChI=1S/C25H19N3O/c29-25-21(16-18-10-4-1-5-11-18)27-24-23(20-14-8-3-9-15-20)26-22(17-28(24)25)19-12-6-2-7-13-19/h1-15,17,26H,16H2

 

Smiles Code:

O=C1C(CC2=CC=CC=C2)=NC3=C(C4=CC=CC=C4)NC(C5=CC=CC=C5)=CN31

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

In Vitro:

Diphenylterazine elicits minimal cell toxicity at millimolar concentrations.

 

In Vivo:

Diphenylterazine injections into untransfected BALB/c mice do not yield any background emission. The bioluminescence resulting from intraperitoneally injected Diphenylterazine displays extended kinetics.

DTZ (0.3 μmol/mouse; i.v.) treatment can track tumor growth in a xenograft NU/J mouse model.

 

 

References

 

  1. Yeh HW, Xiong Y, Wu T, et al. ATP-Independent Bioluminescent Reporter Variants To Improve in Vivo Imaging. ACS Chem Biol. 2019;14(5):959-965. doi:10.1021/acschembio.9b00150

 

Products are for research use only. Not for human use.

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