OUN20985

OUN20985, also known as Homo-PROTAC cereblon degrader 1, is a cereblon degrader.

Product information

CAS Number: 2244520-98-5

Molecular Weight: 660.63

Formula: C32H32N6O10

Synonym:

Homo-PROTAC cereblon degrader 1

OUN-20985

OUN20985

OUN 20985

Chemical Name: 4,4'-(((ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl))bis(azanediyl))bis(2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione)

Smiles: O=C1C2C=CC=C(NCCOCCOCCNC3C=CC=C4C=3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=2C(=O)N1C1CCC(=O)NC1=O

InChiKey: OXIPFLHBDVDLDS-UHFFFAOYSA-N

InChi: InChI=1S/C32H32N6O10/c39-23-9-7-21(27(41)35-23)37-29(43)17-3-1-5-19(25(17)31(37)45)33-11-13-47-15-16-48-14-12-34-20-6-2-4-18-26(20)32(46)38(30(18)44)22-8-10-24(40)36-28(22)42/h1-6,21-22,33-34H,7-16H2,(H,35,39,41)(H,36,40,42)

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

References:

1. Steinebach C, et al. Homo-PROTACs for the Chemical Knockdown of Cereblon. ACS Chem Biol. 2018 Sep 21;13(9):2771-2782.

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