Description
Filastatin is a nontoxic inhibitor of adhesion to human cells, and it affects multiple Candida species. Filastatin blocks the ability of Candida albicans, and other Candida sp. to bind to polystyrene, and human A549 cell monolayers. Filastatin also blocks biofilm formation and yeast-to-hyphal morphologic transition through inhibition of the hyphal-specific promoter HWP1.
Product information
CAS Number: 431996-53-1
Molecular Weight: 359.81
Formula: C18H18ClN3O3
Synonym:
AS-16462
HY-124701
431996-53-1
C18H18ClN3O3
Oprea1_751412
SCHEMBL15506294
AOB4963
SYN5098
EX-A4056
ZINC4758640
STL420152
AKOS003304760
MCULE-6735757823
NCGC00402261-03
CS-0087356
Z57715689
1-(3-chloro-4-methylbenzoyl)-4-(4-nitrophenyl)piperazine
Chemical Name: (3-Chloro-4-methyl-phenyl)-[4-(4-nitro-phenyl)-piperazin-1-yl]-methanone
Smiles: CC1=CC=C(C=C1Cl)C(=O)N1CCN(CC1)C1C=CC(=CC=1)[N+]([O-])=O
InChiKey: PNECWWUOUHGWQG-UHFFFAOYSA-N
InChi: InChI=1S/C18H18ClN3O3/c1-13-2-3-14(12-17(13)19)18(23)21-10-8-20(9-11-21)15-4-6-16(7-5-15)22(24)25/h2-7,12H,8-11H2,1H3
Technical Data
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
References:
- Ahmed Fazly, et al. Chemical screening identifies filastatin, a small molecule inhibitor of Candida albicans adhesion, morphogenesis, and pathogenesis. Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13594-9.
Products are for research use only. Not for human use.
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