Filastatin


Catalog No. size PriceQuantity
M7074-2 2mg solid $100
M7074-3 10mg solid $401

Description

Cas:431996-53-1

Product Information

Filastatin is a nontoxic inhibitor of adhesion to human cells, and it affects multiple Candida species. Filastatin blocks the ability of Candida albicans, and other Candida sp. to bind to polystyrene, and human A549 cell monolayers. Filastatin also blocks biofilm formation and yeast-to-hyphal morphologic transition through inhibition of the hyphal-specific promoter HWP1.

 

Chemical Formula: C18H18ClN3O3

 

Exact Mass: 359.1037

 

Molecular Weight: 359.81

 

Elemental Analysis: C, 60.09; H, 5.04; Cl, 9.85; N, 11.68; O, 13.34

 

Synonym: 

 

431996-53-1

C18H18ClN3O3

Oprea1_751412

SCHEMBL15506294

AOB4963

SYN5098

EX-A4056

ZINC4758640

STL420152

AKOS003304760

MCULE-6735757823

NCGC00402261-03

AS-16462

HY-124701

CS-0087356

Z57715689

1-(3-chloro-4-methylbenzoyl)-4-(4-nitrophenyl)piperazine

 

Chemical Name: (3-Chloro-4-methyl-phenyl)-[4-(4-nitro-phenyl)-piperazin-1-yl]-methanone

 

InChi Key:

PNECWWUOUHGWQG-UHFFFAOYSA-N

 

InChi Code: InChI=1S/C18H18ClN3O3/c1-13-2-3-14(12-17(13)19)18(23)21-10-8-20(9-11-21)15-4-6-16(7-5-15)22(24)25/h2-7,12H,8-11H2,1H3

 

Smiles Code:

O=C(C1=CC=C(C)C(Cl)=C1)N2CCN(C3=CC=C([N+]([O-])=O)C=C3)CC2

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

 

References

 

  1. Ahmed Fazly, et al. Chemical screening identifies filastatin, a small molecule inhibitor of Candida albicans adhesion, morphogenesis, and pathogenesis. Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13594-9.

 

Products are for research use only. Not for human use.

 

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