3-TYP


Catalog No. size PriceQuantity
M7078-2 2mg solid $126
M7078-10 10mg solid $525

Description

Cas:120241-79-4

Product Information

  • TYP is an inhibitor of SIRT3.

 

Chemical Formula: C7H6N4

 

Exact Mass: 146.0592

 

Molecular Weight: 146.15

 

Elemental Analysis: C, 57.53; H, 4.14; N, 38.34

 

Synonym: 

 

3-TYP

3TYP

3 TYP

 

Chemical Name: 

3-(1H-1,2,3-triazol-4-yl) pyridine

 

InChi Key: 

VYXFEFOIYPNBFK-UHFFFAOYSA-N

 

InChi Code: 

InChI=1S/C7H6N4/c1-2-6(4-8-3-1)7-5-9-11-10-7/h1-5H,(H,9,10,11)

 

Smiles Code:

C1(C2=CNN=N2)=CC=CN=C1

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

In Vitro:

  • TYP inhibits melatonin-enhanced SIRT3 activity but does not affect SIRT3 protein expression. 3-TYP pretreatment reverses the protective effects of melatonin on cadmium (Cd)-induced mitochondrial-derived O2•− production and autophagic cell death. 3-TYP significantly attenuates melatonin-induced increases in deacetylated-SOD2 expression and SOD2 activity in HepG2 cells exposed to Cd.

 

In Vivo:

  • TYP (50 mg/kg, i.p.) does not significantly influence the LVEF, LVFS, infarct size, serum LDH levels, apoptosis, and oxidative stress compared with those of the Sham group. Moreover, 3-TYP has little effect on gp91phox, Nrf2, NQO 1, Bax, Bcl-2, Caspase-3, and cleaved Caspase-3 expression levels, compared with the Sham group. 3-TYP significantly decreases SIRT3 activity and increases the acetylation of SOD2 compared with that in the control group, without influencing SIRT3 expression. 3-TYP attenuates the cardioprotective effects of melatonin by decreasing the LVEF and LVFS after 24 hour of reperfusion. 3-TYP also increases the infarct size, serum LDH levels, and apoptotic ratio compared with those in the IR+Mel group.

 

 

References:

        1. Zhai M, Li B, Duan W, Jing L, Zhang B, Zhang M, Yu L, Liu Z, Yu B, Ren K, Gao E,             Yang Y, Liang H, Jin Z, Yu S. Melatonin ameliorates myocardial ischemia                         reperfusion injury through SIRT3-dependent regulation of oxidative stress and             apoptosis. J Pineal Res. 2017 Sep;63(2). doi: 10.1111/jpi.12419. Epub 2017                     Jun PubMed PMID: 28500761.

 

  1. Zeng Z, Yang Y, Dai X, Xu S, Li T, Zhang Q, Zhao KS, Chen Z. Polydatin ameliorates injury to the small intestine induced by hemorrhagic shock via SIRT3 activation-mediated mitochondrial protection. Expert Opin Ther Targets. 2016 Jun;20(6):645-52. doi: 10.1080/14728222.2016.1177023. Epub 2016 Apr 22. PubMed PMID: 27067422.

 

  1. Pi H, Xu S, Reiter RJ, Guo P, Zhang L, Li Y, Li M, Cao Z, Tian L, Xie J, Zhang R, He M, Lu Y, Liu C, Duan W, Yu Z, Zhou Z. SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin. Autophagy. 2015;11(7):1037-51. doi: 10.1080/15548627.2015.1052208. PubMed PMID: 26120888; PubMed Central PMCID: PMC4590599.

 

Products are for research use only. Not for human use.

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