LUN09945


Catalog No. size PriceQuantity
M7084-2 2mg solid $82
M7084-10 10mg solid $316

Description

LUN09945 is a potent RETV804M kinase inhibitor. LUN09945 was first reported by Rebecca Newton et al (Compound 13, in ACS Med Chem Lett. 2020;11(4):497-505). This product has not formal name. For the convenience of scientific communication, we named it by combining its Inchi key (3 letters from the first letter of each section) with the last 5 digits of its CAS number or its molecule weight if its CAS number is not available (see MedKoo Chemical Nomenclature, https://www.medkoo.com/page/naming).

Product information

CAS Number: 2414909-94-5

Molecular Weight: 344.37

Formula: C19H16N6O

Synonym:

LUN-09945

Chemical Name: 4-(5-((pyridin-3-ylmethyl)amino)pyrazolo[1,5-a]pyrimidin-3-yl)benzamide

Smiles: NC(=O)C1C=CC(=CC=1)C1C=NN2C=CC(NCC3=CN=CC=C3)=NC2=1

InChiKey: LMGXQBQAUALFTB-UHFFFAOYSA-N

InChi: InChI=1S/C19H16N6O/c20-18(26)15-5-3-14(4-6-15)16-12-23-25-9-7-17(24-19(16)25)22-11-13-2-1-8-21-10-13/h1-10,12H,11H2,(H2,20,26)(H,22,24)

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

RET V804M-IN-1 (compound 5) exhibits 3.7 and 110 fold selectivity compared to wt-RET and KDR, respectively.

References:

  1. Newton R, Waszkowycz B, Seewooruthun C, et al. Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RETV804M Kinase. ACS Med Chem Lett. 2020;11(4):497-505. Published 2020 Feb 28. doi:10.1021/acsmedchemlett.9b00615

Products are for research use only. Not for human use.

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