DUN73423


Catalog No. size PriceQuantity
M7115-2 2mg solid $120
M7115-10 10mg solid $488

Description

Cas:2414373-42-3

Product Information

DUN73423 is a RET/KDR-Selective Inhibitor of RETV804M Kinase with IC50 = 7 nM. DUN73423 was listed in ACS Med Chem Lett . 2020 Feb 28;11(4):497-505 (compound 5). DUN73423 has CAS#2414373-42-3, no formal name For the convenience of scientific communication, we named it as DUN73423 (combined from Inchi key plus CAS#) according to Hodoodo Chemical Nomenclature.

 

Chemical Formula: C19H16N6O

 

Exact Mass: 344.1386

 

Molecular Weight: 344.378

 

Elemental Analysis: C, 66.27; H, 4.68; N, 24.40; O, 4.65

 

Synonym:

 

DUN73423

DUN-73423

DUN 73423

 

Chemical Name: 4-(5-((pyridin-4-ylmethyl)amino)pyrazolo[1,5-a]pyrimidin-3-yl)benzamide

 

InChi Key:

DICBAYNNPUCOOQ-UHFFFAOYSA-N

 

InChi Code: InChI=1S/C19H16N6O/c20-18(26)15-3-1-14(2-4-15)16-12-23-25-10-7-17(24-19(16)25)22-11-13-5-8-21-9-6-13/h1-10,12H,11H2,(H2,20,26)(H,22,24)

 

Smiles Code:

O=C(N)C1=CC=C(C2=C3N=C(NCC4=CC=NC=C4)C=CN3N=C2)C=C1

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

 

References

 

  1. Newton R, Waszkowycz B, Seewooruthun C, et al. Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RETV804M Kinase. ACS Med Chem Lett. 2020;11(4):497-505. Published 2020 Feb 28. doi:10.1021/acsmedchemlett.9b00615

 

Products are for research use only. Not for human use.

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