ML277


Catalog No. size PriceQuantity
M7123-2 2mg solid $78
M7123-10 10mg solid $324

Description

Cas:1401242-74-7

Product Information

ML277 is a potent activator of KCNQ1 (Kv7.1) channels with >100-fold selectivity versus KCNQ2 and KCNQ4 and no activity against the hERG potassium channel up to 30 μM. KCNQ1 is a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. ML277 is the first selective and potent activator found, with an EC50 of 260 nM.

Chemical Formula: C23H25N3O4S2

 

Exact Mass: 471.1286

 

Molecular Weight: 471.59

 

Elemental Analysis: C, 58.58; H, 5.34; N, 8.91; O, 13.57; S, 13.60

 

Synonym:

 

ML277

ML-277

ML 277

CID-53347902

CID 53347902

CID53347902

VU0458298-2

VU-0458298-2

VU 0458298-2

VU0458298-3

 

Chemical Name: (2R)-N-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylphenyl)sulfonylpiperidine-2-carboxamide,

 

InChi Key:

OXQNLLVUVDAEHC-OAQYLSRUSA-N

 

InChi Code: InChI=1S/C23H25N3O4S2/c1-16-6-12-19(13-7-16)32(28,29)26-14-4-3-5-21(26)22(27)25-23-24-20(15-31-23)17-8-10-18(30-2)11-9-17/h6-13,15,21H,3-5,14H2,1-2H3,(H,24,25,27)/t21-/m1/s1

 

Smiles Code:

O=C([C@@H]1N(S(=O)(C2=CC=C(C)C=C2)=O)CCCC1)NC3=NC(C4=CC=C(OC)C=C4)=CS3

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

 

References

 

  1. Hou P, Shi J, White KM, Gao Y, Cui J. ML277 specifically enhances the fully activated open state of KCNQ1 by modulating VSD-pore coupling. Elife. 2019 Jul 22;8:e48576. doi: 10.7554/eLife.48576. PMID: 31329101; PMCID: PMC6684268.

 

  1. Kanaporis G, Kalik ZM, Blatter LA. Action potential shortening rescues atrial calcium alternans. J Physiol. 2019 Feb;597(3):723-740. doi: 10.1113/JP277188. Epub 2018 Dec 5. PMID: 30412286; PMCID: PMC6355632.

 

  1. Wei X, Zhang Y, Yin B, Wen J, Cheng J, Fu X. The expression and function of KCNQ potassium channels in human chorionic plate arteries from women with normal pregnancies and pre-eclampsia. PLoS One. 2018 Mar 26;13(3):e0192122. doi: 10.1371/journal.pone.0192122. PMID: 29579054; PMCID: PMC5868761.

 

  1. López-Hermoso C, de la Haba RR, Sánchez-Porro C, Ventosa A. Salinivibrio kushneri sp. nov., a moderately halophilic bacterium isolated from salterns. Syst Appl Microbiol. 2018 May;41(3):159-166. doi: 10.1016/j.syapm.2017.12.001. Epub 2017 Dec 21. PMID: 29331569.

 

  1. Tsvetkov D, Kaßmann M, Tano JY, Chen L, Schleifenbaum J, Voelkl J, Lang F, Huang Y, Gollasch M. Do KV 7.1 channels contribute to control of arterial vascular tone? Br J Pharmacol. 2017 Jan;174(2):150-162. doi: 10.1111/bph.13665. Epub 2016 Dec 20. PMID: 28000293; PMCID: PMC5192887.

 

Products are for research use only. Not for human use.

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