Description
ML277 is a potent activator of KCNQ1 (Kv7.1) channels with >100-fold selectivity versus KCNQ2 and KCNQ4 and no activity against the hERG potassium channel up to 30 μM. KCNQ1 is a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. ML277 is the first selective and potent activator found, with an EC50 of 260 nM.
Product information
CAS Number: 1401242-74-7
Molecular Weight: 471.59
Formula: C23H25N3O4S2
Synonym:
ML-277
CID-53347902
VU-0458298-2
ML277
ML 277
CID 53347902
CID53347902
VU0458298-2
VU 0458298-2
VU0458298-3
Chemical Name: (2R)-N-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylphenyl)sulfonylpiperidine-2-carboxamide,
Smiles: CC1C=CC(=CC=1)S(=O)(=O)N1CCCC[C@@H]1C(=O)NC1=NC(=CS1)C1C=CC(=CC=1)OC
InChiKey: OXQNLLVUVDAEHC-OAQYLSRUSA-N
InChi: InChI=1S/C23H25N3O4S2/c1-16-6-12-19(13-7-16)32(28,29)26-14-4-3-5-21(26)22(27)25-23-24-20(15-31-23)17-8-10-18(30-2)11-9-17/h6-13,15,21H,3-5,14H2,1-2H3,(H,24,25,27)/t21-/m1/s1
Technical Data
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
References:
- Hou P, Shi J, White KM, Gao Y, Cui J. ML277 specifically enhances the fully activated open state of KCNQ1 by modulating VSD-pore coupling. Elife. 2019 Jul 22;8:e48576. doi: 10.7554/eLife.48576. PMID: 31329101; PMCID: PMC6684268.
- Kanaporis G, Kalik ZM, Blatter LA. Action potential shortening rescues atrial calcium alternans. J Physiol. 2019 Feb;597(3):723-740. doi: 10.1113/JP277188. Epub 2018 Dec 5. PMID: 30412286; PMCID: PMC6355632.
Products are for research use only. Not for human use.
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