3PO

Cas：18550-98-6

Product Information：

3PO is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) inhibitor. 3PO reduces glycolytic flux and suppresses glucose uptake. 3PO may be useful agents in combination with other drugs that inhibit cancer cell proliferation. PFKFB3 inhibitors suppress glucose uptake, which in turn causes an increase in autophagy. The addition of selective inhibitors of autophagy to 3PO and its more potent derivatives may prove useful as rational combinations for the treatment of cancer. Note: this product has been assigned 2 CAS#: 18550-98-6 and 13309-08-5

Chemical Formula: C13H10N2O

Exact Mass: 210.0793

Molecular Weight: 210.236

Elemental Analysis: C, 74.27; H, 4.79; N, 13.33; O, 7.61

Synonym:

13309-08-5

18550-98-6

(E)-3PO

3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one

CHEMBL3105848

(E)-3-(Pyridin-3-yl)-1-(pyridin-4-yl)prop-2-en-1-one

SCHEMBL196639

(E)-3PO;3PO

CHEBI:144367

BCP34641

ZINC3997313

BDBM50445948

s7639

3PO, >=98% (HPLC)

AKOS025142053

CCG-266648

CS-5491

SB17190

NCGC00386709-03

AS-55969

HY-19824

AB00079158-01

SR-01000203323

SR-01000203323-1

2-Propen-1-one, 3-(3-pyridinyl)-1-(4-pyridinyl)-

3-(pyridin-3-yl)-1-(pyridin-4-yl)prop-2-en-1-one

(2E)-3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one

(E)-3-pyridin-3-yl-1-pyridin-4-ylprop-2-en-1-one (3PO)

(2E)-3-(PYRIDIN-3-YL)-1-(PYRIDIN-4-YL)PROP-2-EN-1-ONE

Chemical Name:

3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one

InChi Key:

UOWGYMNWMDNSTL-ONEGZZNKSA-N

InChi Code: InChI=1S/C13H10N2O/c16-13(12-5-8-14-9-6-12)4-3-11-2-1-7-15-10-11/h1-10H/b4-3+

Smiles Code:

O=C(C1=CC=NC=C1)/C=C/C2=CC=CN=C2

Technical Data：

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

References：

1. Lea MA, Guzman Y, Desbordes C. Inhibition of Growth by Combined Treatment with Inhibitors of Lactate Dehydrogenase and either Phenformin or Inhibitors of 6-Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase 3. Anticancer Res. 2016 Apr;36(4):1479-88. PubMed PMID: 27069123.

2. Biniecka M, Canavan M, McGarry T, Gao W, McCormick J, Cregan S, Gallagher L, Smith T, Phelan JJ, Ryan J, O'Sullivan J, Ng CT, Veale DJ, Fearon U. Dysregulated bioenergetics: a key regulator of joint inflammation. Ann Rheum Dis. 2016 Mar 24. pii: annrheumdis-2015-208476. doi: 10.1136/annrheumdis-2015-208476. [Epub ahead of print] PubMed PMID: 27013493.

3. Saneei A, Pourayoubi M, Crochet A, Fromm KM. The first phosphoramide-mercury(II) complex with a Cl2Hg-OP[N(C)(C)]3 segment. Acta Crystallogr C Struct Chem. 2016 Mar 1;72(Pt 3):230-3. doi: 10.1107/S2053229616002394. Epub 2016 Feb 25. PubMed PMID: 26942433.

4. Nakajima J, Suganami Y, Tsutsumi N, Hirose A, Kondo A, Sunohara D, Kawashima H. Legal Problems Surrounding Medical Care for Neonates Born to International Students: Report of Two Families in Japan. J Immigr Minor Health. 2016 Feb 24. [Epub ahead of print] PubMed PMID: 26911876.

5. Lea MA, Altayyar M, desBordes C. Inhibition of Growth of Bladder Cancer Cells by 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one in Combination with Other Compounds Affecting Glucose Metabolism. Anticancer Res. 2015 Nov;35(11):5889-99. PubMed PMID: 26504012.

6. Maeda M, Kayano E, Fujiwara T, Nagare H, Akao S. Nitrous oxide emissions during biological soil disinfestation with different organic matter and plastic mulch films in laboratory-scale tests. Environ Technol. 2015 Oct 23:1-7. [Epub ahead of print] PubMed PMID: 26370049.

Products are for research use only. Not for human use.