KC01


Catalog No. size PriceQuantity
M7136-2 2mg solid $95
M7136-10 10mg solid $416

Description

Cas:1646795-59-6

Product Information

KC01 is a covalent inhibitor of ABHD16A. ABHD16A is a phosphatidylserine (PS) lipase that generates lyso-PS in mammalian systems. KC01 can deplete lysoPSs from cells, including lymphoblasts derived from subjects with PHARC.

 

Chemical Formula: C22H39NO3

 

Exact Mass: 365.293

 

Molecular Weight: 365.56

 

Elemental Analysis: C, 72.28; H, 10.75; N, 3.83; O, 13.13

 

Synonym:

 

KC01

K C01

K-C01

 

Chemical Name: 

(Z)-6-(2-oxo-4-tridecyloxetan-3-ylidene)hexanamide

 

InChi Key: 

RJBBAPPWVJEOMC-MNDPQUGUSA-N

 

InChi Code: InChI=1S/C22H39NO3/c1-2-3-4-5-6-7-8-9-10-11-14-17-20-19(22(25)26-20)16-13-12-15-18-21(23)24/h16,20H,2-15,17-18H2,1H3,(H2,23,24)/b19-16-

 

Smiles Code:

O=C(N)CCCC/C=C1C(OC\1CCCCCCCCCCCCC)=O

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO (15mg / mL)

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

 

References

 

  1. Kamat SS, Camara K, Parsons WH, Chen DH, Dix MM, Bird TD, Howell AR, Cravatt BF. Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay. Nat Chem Biol. 2015 Feb;11(2):164-71.

 

  1. Parsons, William H.; Kolar, Matthew J.; Kamat, Siddhesh S.; Cognetta, Armand B., III; Hulce, Jonathan J.; Saez, Enrique; Kahn, Barbara B.; Saghatelian, Alan; Cravatt, Benjamin F. AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs. Nature Chemical Biology (2016), 12(5), 367-372.

 

Products are for research use only. Not for human use.

 

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