VH 032 amide-PEG5-acid


Catalog No. size PriceQuantity
M7142-2 2mg solid $75
M7142-10 10mg solid $316

Description

Cas:2172820-14-1

Product Information:

VHL ligand with PEG linker and terminal acid for onward chemistry

 

Biological Activity

Functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development; incorporates an E3 ligase ligand plus a PEG5 linker with terminal carboxylic acid ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

 

Molecular Formula: C36H54N4O11S

 

Molecular Weight:750.9 g/mol

 

StorageStore at -20°C

 

Purity:≥95% (HPLC)

 

Synonyms

 

(S,R,S)-AHPC-PEG5-COOH

2172820-14-1

SCHEMBL19786337

BCP33436

EX-A3940

E3 Ligase Ligand-Linker Conjugates 58

HY-130271

CS-0106354

VH032-PEG5-COOH; VHL Ligand-Linker Conjugates 16; E3 Ligase Ligand-Linker Conjugates 58

 

Chemical Name:

  • [2-[2-[2-[2-[3-[[(2S)-1-[(2S,4R)-4-hydroxy-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid

 

InChI:

InChI=1S/C36H54N4O11S/c1-25-32(52-24-38-25)27-7-5-26(6-8-27)22-37-34(45)29-21-28(41)23-40(29)35(46)33(36(2,3)4)39-30(42)9-11-47-13-15-49-17-19-51-20-18-50-16-14-48-12-10-31(43)44/h5-8,24,28-29,33,41H,9-23H2,1-4H3,(H,37,45)(H,39,42)(H,43,44)/t28-,29+,33-/m1/s1

 

InChI Key:

YDOJYEPMGKGKQV-ZLWRCJDJSA-N

 

Canonical Smiles

CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)CCOCCOCCOCCOCCOCCC(=O)O)O

 

Isomeric Smiles

CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCOCCOCCOCCOCCOCCC(=O)O)O

 

Shipping:

Room temperature in continental US; may vary elsewhere.

 

 

Products are for research use only. Not for human use.

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