Description
Cas：2156588-26-8
Product Information：
Negative control for ARCC 4.
Biological Activity:
Negative control for ARCC 4 (Cat. No. 7254). Binds androgen receptors (AR) without inducing degradation.
Molecular Weight: 1024.18
Formula: C53H56F3N7O7S2
Storage: Store at -20°C
Purity: ≥98% (HPLC)
Chemical Name: (2S,4S)-1-((S)-2-(2-(4-((4'-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-[1,1'-biphenyl]-4-yl)oxy)butoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
InChI Key:
DUPAJELXESPTNF-RNEKHSKBSA-N
Smiles:
CC1=C(C2=CC=C(C=C2)CNC([C@@H]3C[C@@H](CN3C([C@H](C(C)(C)C)NC(COCCCCOC4=CC=C(C5=CC=C(N6C(N(C7=CC(C(F)(F)F)=C(C#N)C=C7)C(C6(C)C)=O)=S)C=C5)C=C4)=O)=O)O)=O)SC=N1
References:
-
Salami et al (2018) Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance. Commun.Biol. 1 100 PMID: 30271980
Products are for research use only. Not for human use.
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