ARCC 4 negative control


Catalog No. size PriceQuantity
M7145-2 2mg solid $146
M7145-10 10mg solid $596

Description

Cas:2156588-26-8

Product Information:

Negative control for ARCC 4.

 

Biological Activity:

Negative control for ARCC 4 (Cat. No. 7254). Binds androgen receptors (AR) without inducing degradation.

 

Molecular Weight: 1024.18

 

Formula: C53H56F3N7O7S2

 

Storage: Store at -20°C

 

Purity: ≥98% (HPLC)

 

Chemical Name: (2S,4S)-1-((S)-2-(2-(4-((4'-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-[1,1'-biphenyl]-4-yl)oxy)butoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

 

InChI Key: 

DUPAJELXESPTNF-RNEKHSKBSA-N

 

Smiles:

CC1=C(C2=CC=C(C=C2)CNC([C@@H]3C[C@@H](CN3C([C@H](C(C)(C)C)NC(COCCCCOC4=CC=C(C5=CC=C(N6C(N(C7=CC(C(F)(F)F)=C(C#N)C=C7)C(C6(C)C)=O)=S)C=C5)C=C4)=O)=O)O)=O)SC=N1

 

 

References:

 

  1. Salami et al (2018) Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance. Commun.Biol. 1 100 PMID: 30271980

 

Products are for research use only. Not for human use.

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