ARCC 4


Catalog No. size PriceQuantity
M7147-2 2mg solid $101
M7147-10 10mg solid $411

Description

Cas:1973403-00-7

Product Information:

ARCC 4 is a PROTAC, acting as an androgen receptor degrader. ARCC-4 is a low-nanomolar androgen receptor degrader able to degrade about 95% of cellular androgen receptors. ARCC-4 inhibits prostate tumor cell proliferation, degrades clinically relevant androgen receptor point mutants and unlike enzalutamide, retains antiproliferative effect in a high androgen environment. Thus, ARCC-4 exemplifies how protein degradation can address the drug resistance hurdles of enzalutamide.

 

Chemical Formula: C53H56F3N7O7S2

 

Exact Mass: 1023.3635

 

Molecular Weight: 1024.1882

 

Elemental Analysis: C, 62.15; H, 5.51; F, 5.56; N, 9.57; O, 10.93; S, 6.26

 

Synonym:

 

ARCC-4

ARCC 4

ARCC4

 

Chemical Name: (2S,4R)-1-[(2S)-2-(2-[4-[4-(4-[3-[4-Cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-sulfanylideneimidazolidin-1-yl]phenyl)phenoxy]butoxy]acetamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide

 

InChi Key:

DUPAJELXESPTNF-PPZGWQTASA-N

 

InChi Code: InChI=1S/C53H56F3N7O7S2/c1-32-45(72-31-59-32)36-11-9-33(10-12-36)28-58-47(66)43-26-40(64)29-61(43)48(67)46(51(2,3)4)60-44(65)30-69-23-7-8-24-70-41-21-16-35(17-22-41)34-13-18-38(19-14-34)63-50(71)62(49(68)52(63,5)6)39-20-15-37(27-57)42(25-39)53(54,55)56/h9-22,25,31,40,43,46,64H,7-8,23-24,26,28-30H2,1-6H3,(H,58,66)(H,60,65)/t40-,43+,46-/m1/s1

 

Smiles Code:

O=C([C@H]1N(C([C@@H](NC(COCCCCOC2=CC=C(C3=CC=C(N(C(N4C5=CC=C(C#N)C(C(F)(F)F)=C5)=S)C(C)(C)C4=O)C=C3)C=C2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC6=CC=C(C7=C(C)N=CS7)C=C6

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

In Vitro

ARCC-4 induces apoptosis and inhibiting proliferation of AR-amplified prostate cancer cells.

ARCC-4 enhances protein-protein interactions between AR and VHL, thereby promoting the association of the trimeric complex.

ARCC-4 (0.1-10,000 nM; 20 hours) potently degrades AR with a D50 of 5 nM and Dmax of over 95%.

ARCC-4 (100 nM; 12 hours) shows near complete AR degradation (>98%) in prostate cancer cells.

ARCC-4 selectively degrades AR via the proteasome but not PR-A or PR-B suppression.

ARCC-4 shows efficacy against clinically relevant AR mutations.

ARCC-4 maintains activity despite elevated androgen levels.

 

 

References

 

  1. Salami J, Alabi S, Willard RR, Vitale NJ, Wang J, Dong H, Jin M, McDonnell DP, Crew AP, Neklesa TK, Crews CM. Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance. Commun Biol. 2018 Aug 2;1:100. doi: 10.1038/s42003-018-0105-8. eCollection 2018. PubMed PMID: 30271980; PubMed Central PMCID: PMC6123676.

 

Products are for research use only. Not for human use.

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