JHU 37160

Catalog No. size PriceQuantity
M7151-2 2mg solid $114
M7151-10 10mg solid $436



Product Information:

High affinity and highly potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant.


Biological Activity:

High affinity and highly potent activator of hM3Dq and hM4Di DREADDs (Ki values are 1.8 nM and 8.7 nM for hM3Dq and hM4Di in vitro, respectively; EC50 values are 5 nM and 0.5 nM for hM3Dq and hM4Di in vitro, respectively). Selectively displaces [3H]clozapine from DREADDs in vivo, but not from other clozapine binding sites. Inhibits locomotor activity in mice expressing hM3Dq and hM4Di in D1-expressing neurons. Brain penetrant in mice, rats and non-human primates.


Chemical Name: 358.85


Formula: C19H20ClFN4


Storage: Store at RT


Purity: ≥98% (HPLC)


Chemical Name: 8-Chloro-11-(4-ethylpiperazin-1-yl)-1-fluoro-5H-dibenzo[b,e][1,4]diazepine


InChI Key:









  1. Bonaventura et al (2019) High-potency ligands for DREADD imaging and activation in rodents and monkeys. Nat.Commun. 10 4627 PMID: 31604917


Products are for research use only. Not for human use.


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