Description
NS 383 is an ASIC blocker. Inhibition was observed at heteromeric ASIC channels. It attenuates pathophysiological nociceptive behaviors in CFA-inflamed and CCI rats.
Product information
CAS Number: 309711-59-9
Molecular Weight: 321.37
Formula: C19H19N3O2
Synonym:
NS 383
NS383
NS-383
Chemical Name: (E)-8-ethyl-3-(hydroxyimino)-5-phenyl-1,3,6,7,8,9-hexahydro-2H-pyrrolo[3,2-h]isoquinolin-2-one
Smiles: CCN1CC2=C3NC(=O)/C(=N/O)/C3=CC(C3C=CC=CC=3)=C2CC1
InChiKey: CHVQAXYXYIDNDC-UHFFFAOYSA-N
InChi: InChI=1S/C19H19N3O2/c1-2-22-9-8-13-14(12-6-4-3-5-7-12)10-15-17(16(13)11-22)20-19(23)18(15)21-24/h3-7,10,24H,2,8-9,11H2,1H3,(H,20,21,23)
Technical Data
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
References:
- Munro et al (2016) NS383 Selectively inhibits acid-sensing ion channels containing 1a and 3 subunits to reverse inflammatory and neuropathic hyperalgesia in rats. CNS Neurosci.Ther. 22 135 PMID: 26663905
Products are for research use only. Not for human use.
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