NS 383 is an ASIC blocker. Inhibition was observed at heteromeric ASIC channels. It attenuates pathophysiological nociceptive behaviors in CFA-inflamed and CCI rats.
CAS Number: 309711-59-9
Molecular Weight: 321.37
Chemical Name: (E)-8-ethyl-3-(hydroxyimino)-5-phenyl-1,3,6,7,8,9-hexahydro-2H-pyrrolo[3,2-h]isoquinolin-2-one
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
- Munro et al (2016) NS383 Selectively inhibits acid-sensing ion channels containing 1a and 3 subunits to reverse inflammatory and neuropathic hyperalgesia in rats. CNS Neurosci.Ther. 22 135 PMID: 26663905
Products are for research use only. Not for human use.
Payment & Security
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.