NS 383


Catalog No. size PriceQuantity
M7154-2 2mg solid $102
M7154-10 10mg solid $406

Description

Cas:309711-59-9

Product Information:

NS 383 is an ASIC blocker. Inhibition was observed at heteromeric ASIC channels. It attenuates pathophysiological nociceptive behaviors in CFA-inflamed and CCI rats.

 

Chemical Formula: C19H19N3O2

 

Exact Mass: 321.1477

 

Molecular Weight: 321.38

 

Elemental Analysis: C, 71.01; H, 5.96; N, 13.08; O, 9.96

 

Synonym: 

 

NS 383

NS383

NS-383

 

Chemical Name: (E)-8-ethyl-3-(hydroxyimino)-5-phenyl-1,3,6,7,8,9-hexahydro-2H-pyrrolo[3,2-h]isoquinolin-2-one

 

InChi Key:

CHVQAXYXYIDNDC-UHFFFAOYSA-N

 

InChi Code: InChI=1S/C19H19N3O2/c1-2-22-9-8-13-14(12-6-4-3-5-7-12)10-15-17(16(13)11-22)20-19(23)18(15)21-24/h3-7,10,24H,2,8-9,11H2,1H3,(H,20,21,23)

 

Smiles Code:

CCN1CCC2=C(C1)C3=C(C=C2C4=CC=CC=C4)/C(C(N3)=O)=N\O

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

 

References:

 

  1. Munro et al (2016) NS383 Selectively inhibits acid-sensing ion channels containing 1a and 3 subunits to reverse inflammatory and neuropathic hyperalgesia in rats. CNS Neurosci.Ther. 22 135 PMID: 26663905

 

Products are for research use only. Not for human use.

 

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