Description
Cas:4049-38-1
Product Information:
(±)-Eriodictyol is a potent TRPV1 antagonist. It inhibits capsaicin-induced Ca2+ influx in synaptosomes and exhibits antinociceptive activity in animal models without affecting body temperature. (±)-Eriodictyol is also an antioxidant that protects against H2O2-induced neurotoxicity in vitro by activation of Nrf2/ARE signaling. Modeling studies predict binding to ACE2 preventing its interaction with SARS-CoV-2 S protein. It is also a naturally-derived flavonoid that is orally bioavailable.
Biological Activity:
Potent TRPV1 antagonist. Inhibits capsaicin (Cat. No. 0462) -induced Ca2+ influx in synaptosomes. Exhibits antinociceptive activity in animal models without affecting body temperature. Also antioxidant; protects against H2O2-induced neurotoxicity in vitro by activation of Nrf2/ARE signaling. Modeling studies predict binding to ACE2 preventing its interaction with SARS-CoV-2 S protein. Naturally-derived flavonoid. Orally bioavailable.
Chemical Formula: C15H12O6
Exact Mass: 288.0634
Molecular Weight: 288.255
Elemental Analysis: C, 62.50; H, 4.20; O, 33.30
Synonym:
(+/-)-Eriodictyol
4049-38-1
Huazhongilexone
MLS000877024
5,7,3',4'-Tetrahydroxyflavanone
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-chroman-4-one
2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-4-one
SMR000440624
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-2,3-dihydrochromen-4-one
4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-
Eriodictyol, (+/-)-
Eriodicytol
3',4',5,7-Tetrahydroxyflavanone
(1)-Eriodictyol
ERIODYCTOL
Flavanone, 3',4',5,7-tetrahydroxy-
(+/-)-3',4',5,7-Tetrahydroxyflavanone
(+/-)-5,7,3',4'-Tetrahydroxyflavanone
Oprea1_736075
BSPBio_002438
cid_11095
SPECTRUM1505145
CHEMBL307893
MEGxp0_000569
SCHEMBL2309591
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-1-benzopyran-4-one
ACon1_000409
BDBM69393
CHEBI:91645
HMS2270F17
AKOS024284394
MCULE-8678602121
NCGC00096019-01
NCGC00096019-02
NCGC00096019-03
ST075648
(+/-)-Eriodictyol, >=95.0% (HPLC)
FT-0686607
NS00014833
B50DD53A-D1B0-4FB5-AC5F-C0F43001B7D8
BRD-A35033682-001-01-0
Q27163470
2-[3,4-bis(oxidanyl)phenyl]-5,7-bis(oxidanyl)-2,3-dihydrochromen-4-one
4H-1-Benzopyran-4-one, 2-(3,4-dihydroxy-phenyl)-2,3-dihydro-5,7-dihydroxy-, (2S)-
Chemical Name:
2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-4-one
InChi Key:
SBHXYTNGIZCORC-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H12O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-5,13,16-19H,6H2
Smiles Code:
OC1=CC(O)=C2C(CC(OC2=C1)C3=CC(O)=C(O)C=C3)=O
Technical Data:
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
References:
-
Smith and Smith et al (2020) Repurposing therapeutics for COVID-19: Supercomputer-based docking to the SARS-CoV-2 viral spike protein and viral spike protein-human ACE2 interface. ChemRxiv - Paper not yet peer reviewed
-
Rossato et al (2011) Eriodictyol: A flavonoid antagonist of the TRPV1 receptor with antioxidant activity. Biochem.Pharmacol. 81 544 PMID: 21087598
-
Lou et al (2012) Eriodictyol protects against H2O2-induced neuron-like PC12 cell death through activation of Nrf2/ARE signaling pathway. Neurochem.Int. 61 251 PMID: 22609376
Products are for research use only. Not for human use.
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