(±)Eriodictyol


Catalog No. size PriceQuantity
M7157-2 2mg solid $128
M7157-10 10mg solid $516

Description

Cas:4049-38-1

Product Information:

(±)-Eriodictyol is a potent TRPV1 antagonist. It inhibits capsaicin-induced Ca2+ influx in synaptosomes and exhibits antinociceptive activity in animal models without affecting body temperature. (±)-Eriodictyol is also an antioxidant that protects against H2O2-induced neurotoxicity in vitro by activation of Nrf2/ARE signaling. Modeling studies predict binding to ACE2 preventing its interaction with SARS-CoV-2 S protein. It is also a naturally-derived flavonoid that is orally bioavailable.

 

 

Biological Activity:

Potent TRPV1 antagonist. Inhibits capsaicin (Cat. No. 0462) -induced Ca2+ influx in synaptosomes. Exhibits antinociceptive activity in animal models without affecting body temperature. Also antioxidant; protects against H2O2-induced neurotoxicity in vitro by activation of Nrf2/ARE signaling. Modeling studies predict binding to ACE2 preventing its interaction with SARS-CoV-2 S protein. Naturally-derived flavonoid. Orally bioavailable.

 

Chemical Formula: C15H12O6

 

Exact Mass: 288.0634

 

Molecular Weight: 288.255

 

Elemental Analysis: C, 62.50; H, 4.20; O, 33.30

 

Synonym: 

 

(+/-)-Eriodictyol

4049-38-1

Huazhongilexone

MLS000877024

5,7,3',4'-Tetrahydroxyflavanone

2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-chroman-4-one

2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-4-one

SMR000440624

2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-2,3-dihydrochromen-4-one

4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-

Eriodictyol, (+/-)-

Eriodicytol

3',4',5,7-Tetrahydroxyflavanone

(1)-Eriodictyol

ERIODYCTOL

Flavanone, 3',4',5,7-tetrahydroxy-

(+/-)-3',4',5,7-Tetrahydroxyflavanone

(+/-)-5,7,3',4'-Tetrahydroxyflavanone

Oprea1_736075

BSPBio_002438

cid_11095

SPECTRUM1505145

CHEMBL307893

MEGxp0_000569

SCHEMBL2309591

2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-1-benzopyran-4-one

ACon1_000409

BDBM69393

CHEBI:91645

HMS2270F17

AKOS024284394

MCULE-8678602121

NCGC00096019-01

NCGC00096019-02

NCGC00096019-03

ST075648

(+/-)-Eriodictyol, >=95.0% (HPLC)

FT-0686607

NS00014833

B50DD53A-D1B0-4FB5-AC5F-C0F43001B7D8

BRD-A35033682-001-01-0

Q27163470

2-[3,4-bis(oxidanyl)phenyl]-5,7-bis(oxidanyl)-2,3-dihydrochromen-4-one

4H-1-Benzopyran-4-one, 2-(3,4-dihydroxy-phenyl)-2,3-dihydro-5,7-dihydroxy-, (2S)-

 

Chemical Name: 

2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-4-one

 

InChi Key:

SBHXYTNGIZCORC-UHFFFAOYSA-N

 

InChi Code: InChI=1S/C15H12O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-5,13,16-19H,6H2

 

Smiles Code:

OC1=CC(O)=C2C(CC(OC2=C1)C3=CC(O)=C(O)C=C3)=O

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

 

References:

 

  1. Smith and Smith et al (2020) Repurposing therapeutics for COVID-19: Supercomputer-based docking to the SARS-CoV-2 viral spike protein and viral spike protein-human ACE2 interface. ChemRxiv - Paper not yet peer reviewed

 

  1. Rossato et al (2011) Eriodictyol: A flavonoid antagonist of the TRPV1 receptor with antioxidant activity. Biochem.Pharmacol. 81 544 PMID: 21087598

 

  1. Lou et al (2012) Eriodictyol protects against H2O2-induced neuron-like PC12 cell death through activation of Nrf2/ARE signaling pathway. Neurochem.Int. 61 251 PMID: 22609376

 

Products are for research use only. Not for human use.

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