(±)-Eriodictyol is a potent TRPV1 antagonist. (±)-Eriodictyol inhibits capsaicin-induced Ca2+ influx in synaptosomes and exhibits antinociceptive activity in animal models without affecting body temperature. (±)-Eriodictyol is also an antioxidant that protects against H2O2-induced neurotoxicity in vitro by activation of Nrf2/ARE signaling. Modeling studies predict binding to ACE2 preventing its interaction with SARS-CoV-2 S protein. It is also a naturally-derived flavonoid that is orally bioavailable.
CAS Number: 4049-38-1
Molecular Weight: 288.25
Chemical Name: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-4-one
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
- Rossato et al (2011) Eriodictyol: A flavonoid antagonist of the TRPV1 receptor with antioxidant activity. Biochem.Pharmacol. 81 544 PMID: 21087598
- Lou et al (2012) Eriodictyol protects against H2O2-induced neuron-like PC12 cell death through activation of Nrf2/ARE signaling pathway. Neurochem.Int. 61 251 PMID: 22609376
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