Description
Cas:2095244-42-9
Product Information:
LCL 161, phenol is a functionalized IAP ligand for PROTACs.
Chemical Formula: C31H42N4O6S
Exact Mass: 598.2825
Molecular Weight: 598.759
Elemental Analysis: C, 62.19; H, 7.07; N, 9.36; O, 16.03; S, 5.35
Synonym:
cIAP1 ligand 1
SCHEMBL21472349
HY-128808
CS-0100093
2095244-42-9
tert-Butyl ((S)-1-(((S)-1-cyclohexyl-2-((S)-2-(4-(3-hydroxybenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate
Chemical Name:
tert-butyl((S)-1-(((S)-1-cyclohexyl-2-((S)-2-(4-(3-hydroxybenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate
InChi Key:
SPXBMEKMIPOEMC-LQGLAIQGSA-N
InChi Code: InChI=1S/C31H42N4O6S/c1-19(34(5)30(40)41-31(2,3)4)27(38)33-25(20-11-7-6-8-12-20)29(39)35-16-10-15-24(35)28-32-23(18-42-28)26(37)21-13-9-14-22(36)17-21/h9,13-14,17-20,24-25,36H,6-8,10-12,15-16H2,1-5H3,(H,33,38)/t19-,24-,25-/m0/s1
Smiles Code:
OC1=CC(C(C2=CSC([C@@H]3CCCN3C([C@@H](NC([C@H](C)N(C)C(OC(C)(C)C)=O)=O)C4CCCCC4)=O)=N2)=O)=CC=C1
Technical Data:
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
References:
-
Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575.
Products are for research use only. Not for human use.
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