FMF-04-159-2


Catalog No. size PriceQuantity
M7178-2 2mg solid $118
M7178-10 10mg solid $494

Description

Cas:2364489-81-4

Product Information:

FMF-04-159-2 targets and inhibits CDK16 via covalent binding to C218.

 

Chemical Formula: C28H30Cl3N7O5S

 

Exact Mass: 681.1095

 

Molecular Weight: 683.0

 

Elemental Analysis: C, 49.24; H, 4.43; Cl, 15.57; N, 14.36; O, 11.71; S, 4.69

 

Synonym:

 

FMF-04-159-2

FMF041592

FMF 04 159 2

 

Chemical Name: (E)-N-(1-((3-(4-(dimethylamino)but-2-enamido)phenyl)sulfonyl)piperidin-4-yl)-4-(2,4,6-trichlorobenzamido)-1H-pyrazole-3-carboxamide

 

InChi Key:

HZPYSAHDRSBARR-QPJJXVBHSA-N

 

InChi Code: InChI=1S/C28H30Cl3N7O5S/c1-37(2)10-4-7-24(39)33-19-5-3-6-20(15-19)44(42,43)38-11-8-18(9-12-38)34-28(41)26-23(16-32-36-26)35-27(40)25-21(30)13-17(29)14-22(25)31/h3-7,13-16,18H,8-12H2,1-2H3,(H,32,36)(H,33,39)(H,34,41)(H,35,40)/b7-4+

 

Smiles Code:

O=C(C1=NNC=C1NC(C2=C(Cl)C=C(Cl)C=C2Cl)=O)NC3CCN(S(=O)(C4=CC=CC(NC(/C=C/CN(C)C)=O)=C4)=O)CC3

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

In Vitro:

FMF-04-159-2 inhibits HCT116 proliferation with an IC50 of 1,144±190 nM.

 

 

References:

 

  1. Ferguson FM, et al. Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity. Cell Chem Biol. 2019 Mar 11. pii: S2451-9456(19)30070-4.

 

Products are for research use only. Not for human use.

 

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