GX 201

GX 201 is a potent and selective Nav1.7 blocker and an analgesic.

Product information

CAS Number: 1788071-27-1

Molecular Weight: 563.00

Formula: C25H27ClF4N2O4S

Synonym:

GX-201

Chemical Name: 4-[[1-[[2-Chloro-5-(trifluoromethyl)phenyl]methyl]-4-piperidinyl]methoxy]-5-cyclopropyl-2-fluoro-N-(methylsulfonyl)benzamide

Smiles: CS(=O)(=O)NC(=O)C1=CC(C2CC2)=C(C=C1F)OCC1CCN(CC2=CC(=CC=C2Cl)C(F)(F)F)CC1

InChiKey: KYBPOTYVFWNSGS-UHFFFAOYSA-N

InChi: InChI=1S/C25H27ClF4N2O4S/c1-37(34,35)31-24(33)20-11-19(16-2-3-16)23(12-22(20)27)36-14-15-6-8-32(9-7-15)13-17-10-18(25(28,29)30)4-5-21(17)26/h4-5,10-12,15-16H,2-3,6-9,13-14H2,1H3,(H,31,33)

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

References:

1. Shields SD, Deng L, Reese RM, et al. Insensitivity to Pain upon Adult-Onset Deletion of Nav1.7 or Its Blockade with Selective Inhibitors. J Neurosci. 2018;38(47):10180-10201. doi:10.1523/JNEUROSCI.1049-18.2018
2. Bankar G, Goodchild SJ, Howard S, et al. Selective NaV1.7 Antagonists with Long Residence Time Show Improved Efficacy against Inflammatory and Neuropathic Pain. Cell Rep. 2018;24(12):3133-3145. doi:10.1016/j.celrep.2018.08.063

Products are for research use only. Not for human use.