ASB 14780

ASB14780 is a potent inhibitor of cPLA2α.

Product information

CAS Number: 1069046-00-9

Molecular Weight: 582.69

Formula: C35H38N2O6

Synonym:

ASB-14780

Chemical Name: 3-[1-(4-Phenoxyphenyl)-3-(2-phenylethyl)-1H-indol-5-yl]propanoic acid tromethamine salt

Smiles: NC(CO)(CO)CO.OC(=O)CCC1=CC2=C(C=C1)N(C=C2CCC1C=CC=CC=1)C1C=CC(=CC=1)OC1C=CC=CC=1

InChiKey: MBPXGBINIINSEU-UHFFFAOYSA-N

InChi: InChI=1S/C31H27NO3.C4H11NO3/c33-31(34)20-13-24-12-19-30-29(21-24)25(14-11-23-7-3-1-4-8-23)22-32(30)26-15-17-28(18-16-26)35-27-9-5-2-6-10-27;5-4(1-6,2-7)3-8/h1-10,12,15-19,21-22H,11,13-14,20H2,(H,33,34);6-8H,1-3,5H2

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

References:

1. Kanai et al (2016) ASB14780, an orally active inhibitor of group IVA phospholipase A2, is a pharmacotherapeutic candidate for nonalcoholic fatty liver disease. J.Pharmacol.Exp.Ther. 356 604 PMID: 26699145
2. Tomoo et al (2014) Design, synthesis, and biological evaluation of 3-(1-aryl-1H-indol-5-yl)propanoic acids as new indole-based cytosolic phospholipase A2α. J.Med.Chem. 57 7244 PMID: 25102418

Products are for research use only. Not for human use.