ASB 14780


Catalog No. size PriceQuantity
M7201-2 2mg solid $127
M7201-10 10mg solid $522

Description

Cas:1069046-00-9

Product Information

ASB14780 is a potent inhibitor of cPLA2α.

 

Chemical Formula: C31H27NO3

 

Exact Mass: 461.1991

 

Molecular Weight: 461.561

 

Elemental Analysis: C, 80.67; H, 5.90; N, 3.03; O, 10.40

 

Synonym:

 

ASB14780

ASB-14780

ASB 14780

 

Chemical Name: 3-[1-(4-Phenoxyphenyl)-3-(2-phenylethyl)-1H-indol-5-yl]propanoic acid tromethamine salt

 

InChi Key:

AVSDLGNMCGTBHT-UHFFFAOYSA-N

 

InChi Code: InChI=1S/C31H27NO3/c33-31(34)20-13-24-12-19-30-29(21-24)25(14-11-23-7-3-1-4-8-23)22-32(30)26-15-17-28(18-16-26)35-27-9-5-2-6-10-27/h1-10,12,15-19,21-22H,11,13-14,20H2,(H,33,34)

 

Smiles Code:

O=C(O)CCC1=CC2=C(N(C3=CC=C(OC4=CC=CC=C4)C=C3)C=C2CCC5=CC=CC=C5)C=C1

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

 

References

 

  1. Kanai et al (2016) ASB14780, an orally active inhibitor of group IVA phospholipase A2, is a pharmacotherapeutic candidate for nonalcoholic fatty liver disease. J.Pharmacol.Exp.Ther. 356 604 PMID: 26699145

 

  1. Tomoo et al (2014) Design, synthesis, and biological evaluation of 3-(1-aryl-1H-indol-5-yl)propanoic acids as new indole-based cytosolic phospholipase A2α. J.Med.Chem. 57 7244 PMID: 25102418

 

Products are for research use only. Not for human use.

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