Description
Cas:1069046-00-9
Product Information:
ASB14780 is a potent inhibitor of cPLA2α.
Chemical Formula: C31H27NO3
Exact Mass: 461.1991
Molecular Weight: 461.561
Elemental Analysis: C, 80.67; H, 5.90; N, 3.03; O, 10.40
Synonym:
ASB14780
ASB-14780
ASB 14780
Chemical Name: 3-[1-(4-Phenoxyphenyl)-3-(2-phenylethyl)-1H-indol-5-yl]propanoic acid tromethamine salt
InChi Key:
AVSDLGNMCGTBHT-UHFFFAOYSA-N
InChi Code: InChI=1S/C31H27NO3/c33-31(34)20-13-24-12-19-30-29(21-24)25(14-11-23-7-3-1-4-8-23)22-32(30)26-15-17-28(18-16-26)35-27-9-5-2-6-10-27/h1-10,12,15-19,21-22H,11,13-14,20H2,(H,33,34)
Smiles Code:
O=C(O)CCC1=CC2=C(N(C3=CC=C(OC4=CC=CC=C4)C=C3)C=C2CCC5=CC=CC=C5)C=C1
Technical Data:
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
References:
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Kanai et al (2016) ASB14780, an orally active inhibitor of group IVA phospholipase A2, is a pharmacotherapeutic candidate for nonalcoholic fatty liver disease. J.Pharmacol.Exp.Ther. 356 604 PMID: 26699145
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Tomoo et al (2014) Design, synthesis, and biological evaluation of 3-(1-aryl-1H-indol-5-yl)propanoic acids as new indole-based cytosolic phospholipase A2α. J.Med.Chem. 57 7244 PMID: 25102418
Products are for research use only. Not for human use.
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