A 410099.1 amide-PEG4-amine


Catalog No. size PriceQuantity
M7213-2 2mg solid $102
M7213-10 10mg solid $401

Description

Cas:2446474-10-6

Product Information

A 410099.1 amide-PEG4-amine, IAP ligand with PEG linker and terminal amine for onward chemistry

 

Biological Activity:

Functionalized IAP ligand for PROTAC® research and development; incorporates an IAP ligand plus an amide-PEG4 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

 

Molecular Weight: 817.02

 

Formula: C42H68N6O10

 

Storage: Store at -20°C

 

Purity: ≥95% (HPLC)

 

Chemical Name:

tert-Butyl((S)-1-(((S)-2-((2S,4S)-4-(14-amino-3,6,9,12-tetraoxatetradecanamido)-2-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate

 

InChI Key:

CDDABGWUXFFTGQ-MLSLTINKSA-N

 

Smiles:

CN([C@H](C(N[C@H](C(N1C[C@@H](NC(COCCOCCOCCOCCN)=O)C[C@H]1C(N[C@@H]2CCCC3=CC=CC=C23)=O)=O)C4CCCCC4)=O)C)C(OC(C)(C)C)=O

 

 

References

 

  1. Tinworth et al (2019) PROTAC-mediated degradation of Bruton's tyrosine kinase is inhibited by covalent binding. ACS Biol.Chem. 14 342 PMID: 30807093

 

Products are for research use only. Not for human use.

 

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