Description
Cas：2446474-11-7
Product Information：
A 410099.1 amide-PEG5-amine, IAP ligand with PEG linker and terminal amine for onward chemistry
Biological Activity:
Functionalized IAP ligand for PROTAC® research and development; incorporates an IAP ligand plus an amide-PEG5 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.
Molecular Weight: 861.09
Formula: C44H72N6O11
Storage: Store at -20°C
Purity: ≥95% (HPLC)
Chemical Name:
tert-Butyl((S)-1-(((S)-2-((2S,4S)-4-(17-amino-3,6,9,12,15-pentaoxaheptadecanamido)-2-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate
InChI Key:
WUQFDZYWJGAVJW-XQVCTUMGSA-N
Smiles:
CN(C(OC(C)(C)C)=O)[C@H](C(N[C@H](C(N1C[C@@H](NC(COCCOCCOCCOCCOCCN)=O)C[C@H]1C(N[C@@H]2CCCC3=CC=CC=C23)=O)=O)C4CCCCC4)=O)C
References：
-
Tinworth et al (2019) PROTAC-mediated degradation of Bruton's tyrosine kinase is inhibited by covalent binding. ACS Chem.Biol. 14 342 PMID: 30807093
Products are for research use only. Not for human use.
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