Lopinavir is an HIV protease inhibitor used in a fixed-dose combination with Ritonavir. It is used against HIV infections as a fixed-dose combination with another protease inhibitor, ritonavir, under the trade names Kaletra and Aluvia. It was first approved by the FDA on 15 September 2000.
CAS Number: 192725-17-0
Molecular Weight: 628.80
Chemical Name: (2S)-N-[(2S,4S,5S)-5-[[2-(2,6-dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO, not in water
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
- Aline F, Aurélie R, Matthias C, Olivier B, Thierry B, Paule SM, Chantal C. Comparison of population pharmacokinetics based on steady-state assumption versus electronically monitored adherence to lopinavir, atazanavir, efavirenz, and etravirine: A retrospective study. Ther Drug Monit. 2016 Mar 1. [Epub ahead of print] PubMed PMID: 26937748.
- Raposo LM, Arruda MB, de Brindeiro RM, Nobre FF. Lopinavir Resistance Classification with Imbalanced Data Using Probabilistic Neural Networks. J Med Syst. 2016 Mar;40(3):69. doi: 10.1007/s10916-015-0428-7. Epub 2016 Jan 6. PubMed PMID: 26733278.
- Patel G, Shelat P, Lalwani A. Statistical modeling, optimization and characterization of solid self-nanoemulsifying drug delivery system of lopinavir using design of experiment. Drug Deliv. 2016 Feb 16:1-16. [Epub ahead of print] PubMed PMID: 26882014.
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