Description
SB297006 is a selective antagonist of CCR3 with IC50 of 39 nM
Product information
CAS Number: 58816-69-6
Molecular Weight: 342.35
Formula: C18H18N2O5
Chemical Name: N-benzoyl-4-nitro-L-phenylalanine, ethyl ester
Smiles: CCOC(=O)[C@H](CC1C=CC(=CC=1)[N+]([O-])=O)NC(=O)C1C=CC=CC=1
InChiKey: BEZXGSZPWXRHIN-INIZCTEOSA-N
InChi: InChI=1S/C18H18N2O5/c1-2-25-18(22)16(19-17(21)14-6-4-3-5-7-14)12-13-8-10-15(11-9-13)20(23)24/h3-11,16H,2,12H2,1H3,(H,19,21)/t16-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO: 68 mg/mL(198.62 mM). Water: Insoluble.
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
SB297006 is a CCR3 antagonist, significantly inhibits proliferation and neurosphere formation in CCL11-treated neural progenitor cells (NPCs) at 100 μM[1].
References:
- Wang F, et al. CCL11 promotes migration and proliferation of mouse neural progenitor cells. Stem Cell Res Ther. 2017 Feb 7;8(1):26.
Products are for research use only. Not for human use.
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