VO-Ohpic Trihydrate

Catalog No. Size PriceQuantity
M7246-2 2mg solid $80
M7246-10 10mg solid $240


VO-Ohpic is an inhibitor of PTEN with IC50 of 35 nM

Product information

CAS Number: 476310-60-8

Molecular Weight: 414.20

Formula: C12H15N2O11V



Chemical Name: Hydroxy(oxo)vanadium 3-hydroxypyridine-2-carboxylic acid complex trihydrate

Smiles: O.O.O.O[V](=O)(OC(=O)C1=NC=CC=C1O)OC(=O)C1=NC=CC=C1O


InChi: InChI=1S/2C6H5NO3.4H2O.O.V/c2*8-4-2-1-3-7-5(4)6(9)10;;;;;;/h2*1-3,8H,(H,9,10);4*1H2;;/q;;;;;;;+3/p-3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 72 mg/mL(173.41 mM). Water: Insoluble.

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

VO-OHpic is a potent small-molecule compound that specifically inhibits PTEN’s cellular enzymatic activity, which in turn activates downstream targets such as Akt and FoxO3a. Glucose uptake into adipocytes is dramatically enhanced upon PTEN inhibition with VO-OHpic. PTEN inhibitor accelerates wound healing in fibroblasts[1]. VO-OHpic inhibits cell viability, cell proliferation and colony formation, and induces senescence-associated β-galactosidase activity in Hep3B (low PTEN expression) and to a lesser extent in PLC/PRF/5 (high PTEN expression) cells, but not in PTEN-negative SNU475 cells[2].

In Vivo:

VO-Ohpic significantly inhibits tumor growth in nude mice bearing xenografts of Hep3B cells[2]. VO-Ohpic administered to C57BL6 mice 30 minutes prior to Kcl-induced asystolic cardiac arrest significantly increases survival, LVPmax and dP/dt max with continued benefit. VO-OHpic also significantly increases lactate clearance and decreases plasma glucose level[3].


  1. Rosivatz E, et al. ACS Chem Biol. 2006,1(12):780-90.
  2. Augello G, et al. Cell Cycle. 2016, 15(4):573-83.
  3. Jing Li, et al. American Heart Association Scientific Sessions. 2013.

Products are for research use only. Not for human use.

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