TRAP-6 is protease-activated receptor 1 (PAR1) agonist.
CAS Number: 141136-83-6
Molecular Weight: 748.87
PAR-1 agonist peptide
Thrombin Receptor Activator Peptide 6
Chemical Name: L-seryl-L-phenylalanyl-L-leucyl-L-leucyl-L-arginyl-L-asparagine
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: H2O : 100 mg/mL (133.53 mM; Need ultrasonic)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
TRAP-6 (0.01-10 μM) triggers calcium mobilization in Xenopus oocytes heterologously expressing PAR1. TRAP-6 (0.01-10 μM; 30 min) activates human platelets. TRAP-6 (100 μM) does not cause the platelets of rabbits or rats to change shape, aggregate, release granule contents, or form thromboxane.
TRAP (1 mg/kg; i.v.) produces a biphasic response in blood pressure in inactin-anesthetized rats.
- Kahn ML, et, al. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. J Clin Invest. 1999 Mar;103(6):879-87.
- Kinlough-Rathbone RL, et, al. Rabbit and rat platelets do not respond to thrombin receptor peptides that activate human platelets. Blood. 1993 Jul 1;82(1):103-6.
- Chintala MS, et, al. Disparate effects of thrombin receptor activating peptide on platelets and peripheral vasculature in rats. Eur J Pharmacol. 1998 May 22;349(2-3):237-43.
Products are for research use only. Not for human use.
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