Ethamsylate


Catalog No. Size PriceQuantity
M7263-2 2 mg solid $65
M7263-10 10 mg solid $90
M7263-100 100 mg solid $250
M7263-C Contact sales@xchem.com for quotation $100

Description

Ethamsylate acts as a haemostatic drug by increasing capillary endothelial resistance and promoting platelet adhesion

Product information

CAS Number: 2624-44-4

Molecular Weight: 263.31

Formula: C10H17NO5S

Synonym:

Etamsylate

E 141

MD 141

Aglumin

Altodor

Eselin

Chemical Name: Benzenesulfonic acid, 2,5-dihydroxy-, compd. with diethylamine

Smiles: CCNCC.OC1=CC(=C(O)C=C1)S(O)(=O)=O

InChiKey: HBGOLJKPSFNJSD-UHFFFAOYSA-N

InChi: InChI=1S/C6H6O5S.C4H11N/c7-4-1-2-5(8)6(3-4)12(9,10)11;1-3-5-4-2/h1-3,7-8H,(H,9,10,11);5H,3-4H2,1-2H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 53 mg/mL(201.28 mM). Water: 53 mg/mL(201.28 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Ethamsylate inhibits prostaglandin bio-synthesis in microsomes of pregnant human myometrium with IC50 of 0.5 mM. [1] Ethamsylate is particularly active against hydroxyl radicals (OH.), which are scavenged at therapeutic Ethamsylate concentrations (0.1–10 μM). Higher Ethamsylate concentrations are required to scavenge superoxide radicals. Ethamsylate potentiates human platelet aggregation and ATP release induced by arachidonic acid, thromboxane A2, collagen, and calcium ionophore A23187. [2]

In Vivo:

Ethamsylate reduces the mean bleeding time when administered systemically or orally to rabbits. By the intravenous route, Ethamsylate reduces bleeding time by half at doses >5 mg/kg. The effect starts 5 minutes after the injection, reaches a maximum between 30 minutes and 4 hours after the injection, and disappears after 6 hours. By the oral route, a similar maximal action is observed at the dose of 10 mg/kg. The efficacy of Ethamsylate to reduce intraventricular hemorrhage is associated with a reduction of thromboxane A2 and prostacyclin biosynthesis. Orally given Ethamsylate (>25 mg/kg) also inhibits carrageenan-induced rat paw edema. [2]

References:

  1. Kovács L, et al. Experientia, 1981, 37(11), 1182-1183
  2. Garay RP, et al. Am J Ther, 2006, 13(3), 236-247.

Products are for research use only. Not for human use.

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