Ro 46-8443

Catalog No. Size PriceQuantity
M7270-2 2mg solid $100
M7270-10 10mg solid $300


Ro 46-8443 is the first non-peptide Endothelin Receptor B selective antagonist with IC50 value of 110nM.

Product information

CAS Number: 175556-12-4

Molecular Weight: 609.69

Formula: C31H35N3O8S

Chemical Name: 4-(tert-butyl)-N-(6-(2,3-dihydroxypropoxy)-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)pyrimidin-4-yl)benzenesulfonamide

Smiles: CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC1=NC(=NC(OCC(O)CO)=C1OC1=CC=CC=C1OC)C1=CC=C(C=C1)OC


InChi: InChI=1S/C31H35N3O8S/c1-31(2,3)21-12-16-24(17-13-21)43(37,38)34-29-27(42-26-9-7-6-8-25(26)40-5)30(41-19-22(36)18-35)33-28(32-29)20-10-14-23(39-4)15-11-20/h6-17,22,35-36H,18-19H2,1-5H3,(H,32,33,34)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO, not in water.

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200


  1. Guimarães CL, Trentin PG, Rae GA. Endothelin ET(B) receptor-mediated mechanisms involved in oleic acid-induced acute lung injury in mice. Clin Sci (Lond). 2002 Aug;103 Suppl 48:340S-344S.
  2. Parent R, Lavallée M. Endothelin-dependent effects limit flow-induced dilation of conductance coronary vessels after blockade of nitric oxide formation in conscious dogs. Cardiovasc Res. 2000 Jan 14;45(2):470-7.
  3. Thorin E, Parent R, Ming Z, Lavallée M. Contribution of endogenous endothelin to large epicardial coronary artery tone in dogs and humans. Am J Physiol. 1999 Aug;277(2 Pt 2):H524-32.

Products are for research use only. Not for human use.

Payment & Security

PayPal Venmo

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed