TH 257

Catalog No. Size PriceQuantity
M7272-2 2mg solid $90
M7272-10 10mg solid $270


TH-257 is a selective LIMK inhibitor with IC50 values of 84nM and 39nM for LIMK1 and LIMK2, respectively.

Product information

CAS Number: 2244678-29-1

Molecular Weight: 422.54

Formula: C24H26N2O3S

Chemical Name: N-Butyl-4-[(phenylamino)sulfonyl]-N-(phenylmethyl)benzamide

Smiles: CCCCN(CC1C=CC=CC=1)C(=O)C1C=CC(=CC=1)S(=O)(=O)NC1C=CC=CC=1


InChi: InChI=1S/C24H26N2O3S/c1-2-3-18-26(19-20-10-6-4-7-11-20)24(27)21-14-16-23(17-15-21)30(28,29)25-22-12-8-5-9-13-22/h4-17,25H,2-3,18-19H2,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 250 mg/mL (591.66 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200


  1. Manetti F. Recent advances in the rational design and development of LIM kinase inhibitors are not enough to enter clinical trials. Eur J Med Chem. 2018 Jul 15;155:445-458.

Products are for research use only. Not for human use.

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