Selamectin is an avermectin derivative prepared by hydrolysis and oximation of doramectin Selamectin is a potent nematocide used for the treatment of parasites which selectively binds to parasite glutamate-gated chloride ion channels and disrupts neurotransmission
CAS Number: 220119-17-5
Molecular Weight: 769.96
Chemical Name: A name could not be generated for this structure.
Smiles: CO[C@@H]1C[C@@H](O[C@@H](C)[C@@H]1O)O[C@H]1[C@@H](C)C=CC=C2CO[C@@H]3/C(=N\O)/C(C)=C[C@@H](C(=O)O[C@H]4C[C@H](CC=C1C)O[C@]1(C4)CC[C@H](C)[C@H](O1)C1CCCCC1)[C@@]23O |c:17,t:15,36|
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : ≥ 100 mg/mL (129.88 mM) H2O : < 0.1 mg/mL (insoluble)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
The transport of radiolabelled Selamectin through Caco-2 monolayers shows that Selamectin is P-glycoprotein (P-gp) substrates with a secretory/absorptive ratio of 4.7. Selamectin inhibits the efflux of Rh-123 from peripheral blood lymphocytes (PBL) and the concentration of inhibition is similar to that of Verapamil.
A single administration of 6 mg/kg topical Selamectin given every two months could effectively prevent B. malayi infection in cats. Application of topical Selamectin twice a year could block circulating microfilariae.
- Patsharaporn T Sarasombath, et al. First study of topical selamectin efficacy for treating cats naturally infected with Brugia malayi and Brugia pahangi under field conditions. Parasitol Res. 2019 Apr;118(4):1289-1297.
- J Griffin, et al. Selamectin is a potent substrate and inhibitor of human and canine P-glycoprotein. J Vet Pharmacol Ther. 2005 Jun;28(3):257-65.
Products are for research use only. Not for human use.
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